Shear wave elastography in hepatitis C patients before and after antiviral therapy

Table 1 Clinical characteristics in the Naïve and sustained virological response group

Characteristics	Naïve group(n = 85)	SVR group(n = 51)	P value
Age (yr)	63.5 ± 13.7	64.9 ± 10.2	0.9726
Sex (male/female)	43/42	27/24	0.79039
AST (IU/L)	55.4 ± 38.7	29.2 ± 16.8	0.00001
ALT (IU/L)	61.9 ± 50.1	23.9 ± 18.0	0.00001
Total bilirubin (mg/dL)	0.89 ± 0.36	0.95 ± 0.33	0.14736
Serum albmin (g/dL)	4.10 ± 0.46	4.32 ± 0.44	0.01049
WBC (× 103/mm3)	5.21 ± 1.83	5.24 ± 1.56	0.79015
Hb (g/dL)	13.9 ± 1.6	14.1 ± 1.5	0.47879
Platelet (× 104/mm3)	14.5 ± 6.4	14.5 ± 5.7	0.89078
Prothrombin activity (%)	97.5 ± 12.1	96.9 ± 13.1	0.98341
AFP (g/dL)	9.6 ± 10.6	5.1 ± 3.3	0.00773
Type IV collagen (ng/mL)	180.5 ± 71.8	179.2 ± 71.6	0.62913
P-III-P (U/mL)	0.92 ± 0.27	0.81 ± 0.31	0.00215
Hyaluronic acid (ng/mL)	191.5 ± 290.3	102.1 ± 93.5	0.24908
M2BPGi (COI)	3.67 ± 4.41	2.03 ± 2.49	0.00546
FIB-4 index	4.44 ± 4.21	3.39 ± 2.63	0.37443

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; WBC: White blood cell; P-III-P: Procollagen III peptide; M2BP: Mac-2 binding protein; COI: Cut-off index.

Table 2 Multiple regression analysis in the Naïve group

	Coefficient (β)	SE(β)	Std β	t-value	df	P value
ALT	0.00261	0.00052	0.4069	5.02998	62	0.00000
Plt	-0.0121	0.00436	-0.27300	0.27300	62	0.00740
PT %	-0.0044	0.00245	-0.1712	1.79923	62	0.07685
Type IV collagen	0.00061	0.00040	0.1578	1.51030	62	0.13605
M2BPGi	0.00844	0.00709	0.1361	1.19098	62	0.23820

ALT: Alanine aminotransferase; Plt: Blood platelet; PT: Prothrombin time; M2BP: Mac-2 binding protein.

Table 3 Multiple regression analysis in the sustained virological response group

	Coefficient (β)	SE (β)	Std β	t-value	df	P value
AFP	0.05564	0.0098	0.5953	5.6797	28	0.00000
Type IV Collagen	-0.0003	0.00066	-0.0626	0.42483	28	0.67420
P-III-P	0.13859	0.17013	0.146	0.81462	28	0.42217
Hyaluronic acid	0.00053	0.00053	0.1658	0.99713	28	0.32724
M2BPGi	0.03554	0.01591	0.2969	2.23421	28	0.03363

AFP: α feto protein; P-III-P: Procollagen III peptide; M2BP: Mac-2 binding protein.