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Copyright ©The Author(s) 2015.
World J Hepatol. May 8, 2015; 7(7): 993-1000
Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.993
Table 1 Diagnostic criteria and assessment of the severity of acute kidney injury according to the criterion of RIFLE, RIFLE/AKIN and KDIGO clinical practice guidelines classifications
Definition of AKIIncreased SCr × 1.5 the basal value presumably to have occurred within the prior 7 d or GFR decrease > 25% or urine output < 0.5 mL/kg per hour for 6 hIncreased SCr × 1.5 the basal value or ≥ 0.3 mg/dL within 48 h or urine output < 0.5 mL/kg per hour for > 6 hIncreased SCr ≥× 1.5 the basal value presumably to have occurred within the prior 7 d or ≥ 0.3 mg/dL (26.5 μmol/L) within 48 h or urine output < 0.5 mL/kg per hour for 6 h
Stage 1 (risk)Increased SCr × 1.5 the basal value or GFR decrease > 25% or urine output< 0.5 mL/kg per hour for 6 hIncreased SCr × 1.5 to 2 the basal value or ≥ 0.3 mg/dL within 48 h or urine output < 0.5 mL/kg per hour for > 6 hIncreased SCr × 1.5 to 1.9 the basal value or ≥ 0.3 mg/dL or urine output < 0.5 mL/kg per hour for 6-12 h
Stage 2 (injury)Increased SCr × 2 the basal value or GFR decrease > 50% or urine output < 0.5 mL/kg per hour for 12 hIncreased SCr × 2 to 3 the basal value or urine output < 0.5 mL/kg per hour for > 12 hIncreased SCr × 2 to 2.9 the basal value or urine output < 0.5 mL/kg per hour for ≥ 12 h
Stage 3 (failure)Increased SCr × 3 the basal value or GFR decrease > 75% or SCr > 4 mg/dL with acute rise of ≥ 0.5 mg/dL or urine output < 0.3 mL/kg per hour for 24 h or anuria for 12 hIncreased SCr × 3 the basal value or ≥ 4 mg/dL (353.6 μmoL/L) with acute rise ≥ 0.5 mg/dL or initiation of RRT or urine output < 0.3 mL/kg per hour for ≥ 24 h or anuria for ≥ 12 hIncreased SCr × 3 the basal value or ≥ 4 mg/dL (353.6 μmol/L) or initiation of RRT or urine output < 0.3 mL/kg per hour for ≥ 24 h or anuria for ≥ 12 h
Table 2 Diagnostic criteria of type 1 hepatorenal syndrome porposed by the international ascites club[25]
Cirrhosis with ascites
SCr > 1.5 mg/dL (133 μmol/L)
Doubling of basal SCr to a level greater than 2.5 mg/dL (226 μmol/L) in less than 2 wk
No improvement in SCr (decrease to 1.5 mg/dL or less) after at least 2 d of diuretic withdrawal and expansion of plasma volume with albumin (1 g/kg body weight/d up to a maximum of 100 g/d)
Absence of shock
No current or recent treatment with nephrotoxic drugs or vasodilators
Absence of parenchymal kidney disease as indicated by proteinuria > 0.5 g/d, hematuria (> 50 red blood cells per high-power field), or abnormal renal ultrasonography