Effect of hepatic venous pressure gradient in different hepatic venous branches on assessing portal hypertension in cirrhotic patients

Table 1 Baseline characteristics of patients in sub-study 1

	All (n = 73)	HBV (n = 43)	ALD (n = 20)	HBV + ALD (n = 10)
Age (year), mean ± SD	53.58 ± 9.10	55.50 ± 9.00	51.10 ± 9.51	50.60 ± 10.24
Male	61 (83.6)	32 (74.4)	19 (95.0)	10 (100.0)
BMI (kg/m2)	22.84 (3.28)	22.12 (3.14)	23.48 (3.36)	23.57 (3.04)
Decompensation, n (%)	59 (80.8)	37 (86.0)	13 (65.0)	9 (90.0)
Variceal bleeding	54 (74.0)	36 (83.7)	9 (45.0)	9 (90.0)
Ascites needing treatment	11 (15.1)	4 (9.3)	5 (25.0)	2 (20.0)
Hepatic encephalopathy	1 (1.4)	0 (0)	1 (5.0)	0 (0)
CSPH, n (%)	63 (86.3)	35 (81.4)	18 (90.0)	10 (100.0)
Etiology, n (%)
HBV	43 (58.9)	NA	NA	NA
ALD	20 (27.4)	NA	NA	NA
HBV and ALD	10 (13.7)	NA	NA	NA
Child-Pugh class, n (%)
Class A	52 (71.2)	35 (81.4)	11 (55.0)	6 (60.0)
Class B	18 (24.6)	7 (16.3)	7 (35.0)	4 (40.0)
Class C	3 (4.1)	1 (2.3)	2 (10.0)	0 (0)
Laboratory test, median (IQR)
PLT (109/L)	54.00 (11.00)	72.00 (52.50)	87.00 (54.75)	72.00 (33.00)
TBIL (μmol/L)	19.60 (19.25)	15.40 (11.10)	27.90 (27.35)	22.35 (22.90)
Hb (109/L)	101.00 (43.00)	109.00 (46.00)	101.00 (50.00)	76.50 (47.50)
ALT (U/L)	25.00 (20.00)	24.00 (15.00)	29.00 (22.25)	25.00 (13.00)
AST (U/L)	34.00 (24.50)	30.00 (13.50)	62.00 (73.75)	40.00 (20.00)
GGT (U/L)	41.50 (67.50)	35.00 (31.25)	132.00 (194.00)	27.00 (57.00)
Alb (g/L)	34.55 (6.50)	37.20 (9.00)	33.00 (5.70)	33.20 (3.90)
Cr (μmol/L)	68.00 (21.00)	72.00 (23.50)	61.00 (15.25)	65.50 (18.00)
PT (seconds)	15.90 (2.50)	15.85 (2.70)	15.95 (3.10)	16.50 (2.10)
INR	1.27 (0.26)	1.26 (0.27)	1.30 (0.32)	1.34 (0.23)

HBV: Hepatitis B virus; ALD: Alcoholic-related liver disease; BMI: Body mass index; CSPH: Clinically significant portal hypertension; IQR: Interquartile range; PLT: Platelet counts; TBIL: Total bilirubin; Hb: Hemoglobin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transpeptidase; Alb: Albumin; Cr: Creatinine; PT: Prothrombin time; INR: International normalized ratio.

Table 2 Baseline characteristics of patients in sub-study 2

	All (n = 16)
Age (year), mean ± SD	50.50 ± 10.73
Male, n (%)	13 (81.3)
HVPG, mean ± SD	23.44 ± 4.29
PPG, mean ± SD	23.63 ± 4.22
Etiology, n (%)
HBV	13 (81.3)
ALD	3 (18.7)
Child-Pugh class, n (%)
Class A	9 (56.3)
Class B	6 (37.5)
Class C	1 (6.2)
Laboratory test, median (IQR)
PLT (109/L)	78.50 (90.5)
TBIL (μmol/L)	26.00 (37.90)
Alb (g/L)	33.90 (8.80)
PT (seconds)	16.65 (1.50)

HVPG: Hepatic venous pressure gradient; PPG: Portal pressure gradient; HBV: Hepatitis B virus; ALD: Alcoholic-related liver disease; IQR: Interquartile range; PLT: Platelet counts; TBIL: Total bilirubin; Alb: Albumin; PT: Prothrombin time.

Table 3 Measurement of right hepatic venous pressure gradient, middle hepatic venous pressure gradient and left hepatic venous pressure gradient, mean ± SD

	R-HVPG	M-HVPG	L-HVPG
All	16.43 ± 5.34	16.98 ± 5.69	15.29 ± 5.22
HBV	15.60 ± 5.13	16.65 ± 5.55	14.53 ± 5.21
ALD	17.65 ± 6.25	18.10 ± 5.99	15.74 ± 4.47
HBV + ALD	17.60 ± 3.89	16.30 ± 5.98	17.78 ± 6.34

HVPG: Hepatic venous pressure gradient; HBV: Hepatitis B virus; ALD: Alcoholic-related liver disease.

Table 4 Agreement of right hepatic venous pressure gradient, middle hepatic venous pressure gradient and left hepatic venous pressure gradient

	R-HVPG-M-HVPG	R-HVPG-L-HVPG	M-HVPG-L-HVPG
All	0.70 (0.56-0.80)	0.56 (0.37-0.70)	0.47 (0.27-0.63)
HBV	0.70 (0.51-0.82)	0.56 (0.31-0.74)	0.55 (0.31-0.72)
ALD	0.63 (0.26-0.84)	0.65 (0.33-0.83)	0.42 (0.01-0.71)
HBV + ALD	0.83 (0.63-0.93)	0.22 (0-0.71)	0.26 (0-0.75)

L-HVPG: Left hepatic venous pressure gradient; M-HVPG: Middle hepatic venous pressure gradient; R-HVPG: Right hepatic venous pressure gradient; HBV: Hepatitis B virus; ALD: Alcoholic-related liver disease.