Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
Effect of hepatic venous pressure gradient in different hepatic venous branches on assessing portal hypertension in cirrhotic patients
Yi-Fei Huang, Xiao-Qin Wu, Yi-Dong Yang, Bi-Lun Ke, Jin-Ni Luo, Xiao-Li Huang, Xue-Mei Pan, Xue-Mei Lai, Li-Jun Zhang, Bin Wu, Department of Gastroenterology, Alcohol-related Liver Disease Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Yi-Fei Huang, Xiao-Qin Wu, Yi-Dong Yang, Bi-Lun Ke, Jin-Ni Luo, Xiao-Li Huang, Xue-Mei Pan, Xue-Mei Lai, Li-Jun Zhang, Bin Wu, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou 510630, Guangdong Province, China
Bo-Yang Chang, Chu-Ren Zhou, Chun Wu, Department of Interventional Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Co-first authors: Yi-Fei Huang and Xiao-Qin Wu.
Co-corresponding authors: Chun Wu and Bin Wu.
Author contributions: Huang YF and Wu B contributed to study concept and design; Huang YF and Wu XQ contributed equally to this manuscript as co-first authors; Wu XQ, Yang YD, Ke BL, Luo JN, Chang BY, Zhou CR, Huang XL, Pan XM, Lai XM, Zhang LJ, and Wu C contributed to acquisition of data and technique support; Huang YF contributed to drafting of the manuscript; Wu B and Wu C contributed to critical revision of the manuscript, and they contributed equally to this manuscript as co-corresponding authors. All authors read and approved the final manuscript.
AI contribution statement: No AI tools were used in the preparation of this manuscript.
Supported by Youth S&T Talent Support Program of Guangdong Provincial Association for Science and Technology (GDSTA), No. SKXRC2025129; Natural Science Foundation of Guangdong Province, No. 2025A1515012900; Scientific and Technological Planning Project of Guangzhou City, No. 2025A04J4250; and Cultivation Program for National Natural Science Foundation of The Third Affiliated Hospital of Sun Yat-sen University, No. 2025GZRPYQN04.
Institutional review board statement: The study protocol conformed to the ethical guidelines of the Declaration of Helsinki and was approved by the ethics committee of The Third Affiliated Hospital of Sun Yat-Sen University (approval No. RG2024-195-01).
Clinical trial registration statement: This study is registered at https://www.clinicaltrials.gov/. The registration identification No. NCT06358092.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: Deidentified individual participant data will not be shared. Researchers can apply for data by submitting a proposal to the corresponding author.
Corresponding author: Bin Wu, MD, PhD, Professor, Senior Researcher, Department of Gastroenterology, Alcohol-related Liver Disease Center, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe District, Guangzhou 510630, Guangdong Province, China.
Received: May 22, 2026
Revised: June 22, 2026
Accepted: July 16, 2026
Published online: August 27, 2026
Processing time: 88 Days and 13 Hours
Revised: June 22, 2026
Accepted: July 16, 2026
Published online: August 27, 2026
Processing time: 88 Days and 13 Hours
Core Tip
Core Tip: Middle hepatic venous pressure gradient (M-HVPG) achieves the highest technical success rate and superior agreement with right hepatic venous pressure gradient (HVPG) than that of left HVPG. M-HVPG potentially reflects accurate portal pressure. M-HVPG may be considered a preferred alternative when right HVPG is unfeasible or unreliable.