Prognostic power of dynamic enhancement in advanced chronic liver disease: Moving beyond static liver structure

doi:10.4254/wjh.116709

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Jul 27, 2026; 18(7): 116709
Published online Jul 27, 2026. doi: 10.4254/wjh.116709

Table 1 Comparative strategic utility of magnetic resonance imaging-functional liver imaging score vs contrast-enhanced ultrasound

Modality	Parameter	Strategic strength	Clinical constraint
MRI-Functional Liver Imaging Score	Uptake (organic anion-transporting polypeptides), excretion (multidrug resistance associated protein 2), and portal flow	Comprehensive assessment of cellular health and reserve[2,4,21]	High cost; inter-scanner variability; renal contraindications[6,8]
MRI-hepatic enhancement	Segment VI quantitative signal intensity	Objective and continuous metric; strong mortality predictor[1]	Logistical complexity; manual regions of interest placement; single-center limits[1]
Contrast-enhanced ultrasound	Hepatic vein arrival time and transit times	Real-time microvascular profiling; bedside-ready; low cost[10,15,18]	Operator-dependent; no hepatocyte-specific phase[19,20]

MRI: Magnetic resonance imaging.

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Citation: Giangregorio F. Prognostic power of dynamic enhancement in advanced chronic liver disease: Moving beyond static liver structure. World J Hepatol 2026; 18(7): 116709
URL: https://www.wjgnet.com/1948-5182/full/v18/i7/116709.htm
DOI: https://dx.doi.org/10.4254/wjh.116709

Giangregorio F. Prognostic power of dynamic enhancement in advanced chronic liver disease: Moving beyond static liver structure. World J Hepatol 2026; 18(7): 116709 [DOI: 10.4254/wjh.116709]

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