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Prognostic power of dynamic enhancement in advanced chronic liver disease: Moving beyond static liver structure
Francesco Giangregorio, Department of Internal Medicine, Castel San Giovanni Hospital, Piacenza 29015, Emilia-Romagna, Italy
Author contributions: Giangregorio F wrote the original draft.
AI contribution statement: I didn’t use any artificial intelligence for writing this paper. I only use Notebook LM for the first English grammar correction of the text.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Corresponding author: Francesco Giangregorio, MD, Associate Professor, Chief Physician, Director, Department of Internal Medicine, Castel San Giovanni Hospital, Viale II Giugno 1, Castel San Giovanni, Piacenza 29015, Emilia-Romagna, Italy. f.giangregorio67@gmail.com
Received: November 18, 2025
Revised: November 25, 2025
Accepted: January 7, 2026
Published online: July 27, 2026
Processing time: 248 Days and 10.2 Hours
Revised: November 25, 2025
Accepted: January 7, 2026
Published online: July 27, 2026
Processing time: 248 Days and 10.2 Hours
Core Tip
Core Tip: Current approaches in hepatology increasingly emphasize functional assessment in addition to structural evaluation. While magnetic resonance imaging-derived scores, such as the functional liver imaging score, offer relevant prognostic information, their practical limitations, including cost and technical variability, may restrict widespread use. In contrast, contrast-enhanced ultrasound offers a widely accessible technique for dynamic hemodynamic assessment. The future of clinical practice lies in a stepwise diagnostic approach – utilizing simpler bedside tests for broad screening while reserving advanced magnetic resonance imaging for high-risk cases to support broader implementation of personalized liver care.