Transforming growth factor beta reduces proprotein convertase subtilisin/kexin type 9 in the supernatant of hepatic stellate cells

doi:10.4254/wjh.v18.i1.113896

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Jan 27, 2026 (publication date) through Jan 27, 2026

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jan 27, 2026; 18(1): 113896
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.113896

Table 1 Proprotein convertase subtilisin/kexin type 9 levels in supernatants of primary liver cells and cell lines, mean ± SD

Cells	LX-2	HSC	PHH	Huh7	HepG2	HHSEC	KC
Number of cultures	6	9		16	5
Number of donors			10			3	2
PCSK9 (ng/mL)	6.8 ± 1.7	1.7 ± 1.5	2.4 ± 0.5	17.2 ± 6.9	27.0 ± 1.5	0.2 ± 0.1	0.1 ± 0.0

Proprotein convertase subtilisin/kexin type 9 protein levels of 10⁶ cells are listed in the table. PCSK9: Proprotein convertase subtilisin/kexin type 9; HSC: Hepatic stellate cell; PHH: Primary human hepatic; HHSEC: Human hepatic sinusoidal endothelial cell; KC: Kupffer cell.

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Citation: Bundschuh J, Neumann M, Zimny S, Spirk M, Buechler C. Transforming growth factor beta reduces proprotein convertase subtilisin/kexin type 9 in the supernatant of hepatic stellate cells. World J Hepatol 2026; 18(1): 113896
URL: https://www.wjgnet.com/1948-5182/full/v18/i1/113896.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i1.113896