Clinical characteristics and genetic causes of unexplained pediatric liver disease

Table 1 Demographic and clinical characteristics of the study population, n (%)

Characteristics	Group A (n = 65)	Group B (n = 15)
Male gender	36 (55.4)	6 (40.0)
Age (median, IQR), (months)	36.0 (11.0, 84.0)	13.0 (4.0, 49.5)
History of liver disease (median, IQR), (months)	2.0 (1.0, 7.0)	2.0 (1.0, 4.0)
Loss to follow-up	5 (7.7)	1 (6.7)
Liver function recovery	48 (73.8)	7 (46.7)
liver transplantation	0 (0.0)	1 (6.7)

IQR: Interquartile range.

Table 2 Reference intervals of commonly used biochemical test items in clinical practice for Chinese children

Items	Age	Reference interval, U/L
		Male	Female
Alanine transaminase	28 days to < 1 year	8-71
	1 year to < 2 years	8-42
	2 years to < 13 years	7-30
	13 to 18 years	7-43	6-29
Aspartate aminotransferase	28 days to < 1 year	21-80
	1 year to < 2 years	22-59
	2 years to < 13 years	14-44
	13 to 18 years	12-37	10-31
Gamma-glutamyl transferase	28 days to < 6 months	9-150
	6 months to < 1 year	6-31
	1 year to < 13 years	5-19
	13 to 18 years	8-40	6-26