Predictors of portal vein thrombosis after splenectomy in patients with cirrhosis

Table 1 Demonthsgraphic and clinical characteristics of the study population at baseline

Variables	Data
Gender
Men, n (%)	21 (46.7)
Female, n (%)	24 (53.3)
Age (yr)	47.62 ± 11.16
Etiology
HBV, n (%)	37 (74.0)
HCV, n (%)	2 (4.0)
AIH, n (%)	4 (8.0)
Unexplained cirrhosis, n (%)	2 (4.0)
WBC (109/L)	2.21 ± 1.18
RBC (1012/L)	3.68 ± 0.78
PLT (109/L)	44.09 ± 28.54
AST (U/L)	35.18 ± 14.82
ALT (U/L)	26.89 ± 14.30
TBIL (μmol/L)	26.77 ± 15.97
ALB (g/L)	38.81 ± 4.16
INR	1.30 ± 0.19
PT (s)	14.23 ± 1.94
PTA (%)	68.71 ± 13.45
D-D2 (mg/L)	0.56 ± 1.03
MELD	10.76 ± 3.30
PVD (mm)	13.66 ± 2.49
PV (cm/s)	19.87 ± 5.88
SVD (mm)	10.35 ± 2.61
Ascites, n (%)	19 (42.2)
Child-Pugh grade
A, n (%)	32 (71.1)
B, n (%)	13 (28.9)
C, n (%)	0 (0.0)
Operation ways	1.30 ± 0.19
Open splenectomy, n (%)	35 (78.8)
Laparoscopic splenectomy, n (%)	10 (21.2)
Spleen volume (cm3)	2349.28 (531.12-13080.00)

HBV: Hepatitis B virus; HCV: Hepatitis C virus; AIH: Autoimmune hepatitis; WBC: White blood cell counts; RBC: Red blood cell counts; PLT: Platelet counts; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; TBIL: Total bilirubin; ALB: Albumin; INR: International normalized ratio; PT: Prothrombin time; PTA: Prothrombin activity; MELD: Monthsdel for end-stage liver disease; PVD: Portal vein diameter; PV: Portal vein velocity; SVD: Splenic vein.

Table 2 Independent risk factors of portal vein thrombosis formation in patients with liver cirrhosis after splenectomy

Variable	PVT	Non-PVT	P value	OR	95%CI
Postoperative 1-month
Age	45.72 ± 7.84	48.89 ± 12.91
PVD	14.79 ± 2.08	12.60 ± 2.38	0.028	2.194	1.090-4.415
MELD > 10	12 (70.6)	8 (32.0)	0.013	76.215	2.534-2287.318
PLT	47.00 ± 41.96	42.15 ± 14.78
Postoperative 3-months
Age	44.71 ± 7.96	44.71 ± 7.96
PT	14.69 ± 1.94	14.69 ± 1.94
PVD	14.71 ± 2.16	14.71 ± 2.16	0.03	1.7	1.052-2.746
Meld > 10	12 (70.6)	8 (32.0)	0.028	12.392	1.318-116.548
PLT	47.57 ± 38.80	41.04 ± 15.11
Postoperative 12-months
Age	44.64 ± 7.77	50.4 ± 13.19
PVD	14.60 ± 2.13	12.64 ± 2.47	0.037	1.776	1.036-3.046
MELD > 10	14 (63.6)	6 (26.1)	0.015	23.925	1.875-305.323
PLT	46.55 ± 38.17	41.74 ± 15.05

PVT: Portal vein thrombosis; OR: Odd ratio; CI: Confidence interval; PVD: Portal vein diameter; MELD: Monthsdel for end-stage liver disease; PLT: Platelet counts.