Current status and prospect of treatments for recurrent hepatocellular carcinoma

Table 1 Overall survival and recurrence-free survival after re-resection for hepatocellular carcinoma recurrence

Ref.	Type	Year	n	1-, 3-, and 5-yr OS	1-, 3-, and 5-yr RFS
Huang et al[83]	Retrospective	1995-2010	82	71%/41%/22%	N/A
Itamoto et al[168]	Retrospective	1990-2004	84	88%/67%/50%	-/-/10%
Li et al[169]	Retrospective	1997-2015	103	92%/-/54%	N/A
Lu et al[81]	Retrospective	2004-2015	138	92%/82%/73%	N/A
Ho et al[103]	Retrospective	2001-2007	54	90%/-/72%	N/A
Sun et al[170]	Retrospective	1997-2003	57	70%/61%/31%	N/A
Wang et al[104]	Retrospective	2004-2010	128	98%/84%/64%	95%/72%/43%
Roayaie et al[171]	Retrospective	1994-2009	35	-/-/67%	-/55%/-
Faber et al[80]	Retrospective	1990-2009	27	96%/70%/42%	70%/46%/30%
Liu et al[87]	Retrospective	2008-2015	30	97%/85%/75%	79%/46%/30%
Sun et al[172]	Retrospective	2002-2014	43	98%/83%/56%	57%/32%/29%
Song et al[173]	Retrospective	1994-2012	39	89%/89%/84%	66%/49%/43%
Chan et al[93]	Retrospective	2001-2008	45	90%/57%/35%	41%/24%/24%

OS: Overall survival; RFS: Recurrence-free survival; HCC: Hepatocellular carcinoma; N/A: Not applicable.

Table 2 Overall survival and recurrence-free survival after salvage transplantation for recurrent hepatocellular carcinoma

Ref.	Type	Years	n	1-, 3-, and 5-yr OS	1-, 3-, and 5-yr RFS
Guerrini et al[174]	Retrospective	2000-2011	28	-/-/42%	N/A
Chan et al[175]	Retrospective	2005-2017	776	96%/75%/67%	89%/68%/68%
Chan et al[176]	Retrospective	1993-2009	19	-/-/50%	68%/58%/58%
Bhangui et al[177]	Prospective	-	31	-/-/54%	-/-/48%
Shan et al[178]	Retrospective	2006-2015	45	65%/53%/42%	48%/32%/32%
Liu et al[179]	Retrospective	2001-2011	39	88%/78%/61%	14%/24%/33%
Hu et al[180]	Retrospective	1999-2009	888	73%/52%/46%	N/A
Wang et al[181]	Prospective	2001-2013	74	88%/79%/62%	87%/74%/67%

OS: Overall survival; RFS: Recurrence-free survival; HCC: Hepatocellular carcinoma; N/A: Not applicable.

Table 3 Overall survival and recurrence-free survival after ablation therapy for recurrent hepatocellular carcinoma

Ref.	Type	Years	n	1-, 3-, and 5-yr OS	1-, 3-, and 5-yr RFS
Sun et al[172]	Retrospective	2002-2014	57	98%/77%/53%	61%/27%/17%
Ho et al[103]	Retrospective	2001-2007	54	-/-/83%	N/A
Liang et al[182]	Retrospective	1999-2007	66	77%/49%/40%	N/A
Song et al[173]	Retrospective	1994-2012	178	99%/83% 71%	70%/41%/30%
Zhang et al[183]	Retrospective	2007-2014	50	100%/64%/64%	N/A
Feng et al[184]	Retrospective	2006-2016	199	91%/69%/56%	57%/28%/15%
Chan et al[93]	Retrospective	2001-2008	45	84%/43%/29%	32%/12%/9%
Koh et al[185]	Retrospective	2002-2011	42	-/-/24%	N/A
Chen et al[186]	Retrospective	2009-2015	57	78%/41%/37%	70%/38%/33%
Lu et al[81]	Retrospective	2004-2015	194	94%/75%/62%	N/A
Wang et al[104]	Retrospective	2004-2010	162	97%/73%/37%	90%/54%/27%

OS: Overall survival; RFS: Recurrence-free survival; HCC: Hepatocellular carcinoma; N/A: Not applicable.