Non-alcoholic fatty liver disease: Is surgery the best current option and can novel endoscopy play a role in the future?

Table 1 illustrates the non-alcoholic fatty liver disease activity scoring system

Group	Definition	Scoring
Steatosis	< 5%	0
	5%-33%	1
	> 33%-66%	2
	> 66%	3
Lobular inflammation	No foci	0
	< 2 foci per 200× field	1
	2-4 foci per 200× field	2
	> 4 foci per 200× field	3
Hepatocyte ballooning	None	0
	Few	1
	Many	2
Fibrosis	No fibrosis	0
	Zone 3 mild perisinusoidal fibrosis	1a
	Zone 3 moderate perisinusoidal fibrosis	1b
	Periportal/portal fibrosis only	1c
	Zone 3+ periportal/portal fibrosis	2
	Bridging fibrosis	3
	Cirrhosis	4

Overview of the components of the non-alcoholic fatty liver disease activity score scoring system.

Table 2 Characteristics of patients who underwent intra-gastric balloons insertion

Variable	2014-2016, n (%)	2017-2018, n (%)
Total IGBs	172	67
Total number of patients	127	60
Age (yr) (mean; min-max)	46.8 (11.9;19-73)	46.6 (11.7;21-67)
Sex
Male	56 (27)	17 (25)
Female	126 (73)	50 (75)
Baseline weight (kg) (mean; min-max)	110.0 (19.5;67-173.3)	114.6 (21.6;70-165)
Balloon number
1	102 (59)	41 (61)
2	46 (27)	14 (20)
3	19 (11)	5 (7)
4	5 (3)	3 (4)
5	-	2 (3)
6	-	2 (3)

IGB: Intra-gastric balloons.

Table 3 Comparison weight loss

Variable	2014-2016	2017-2018
Baseline weight (kg) (mean)	110.0 (19.5)	114.6 (21.6)
Weight at removal (kg) (mean)	101 (19.8)	103.5 (21.2)
Weight loss (kg) (mean)	8.9 (8.6)	10.2 (6.8)
Weight loss as %BW (%) (mean)	7.9 (7.5)	9.1 (6.1)