Cardiac stress testing and coronary artery disease in liver transplantation candidates: Meta-analysis

Table 1 Studies included in analysis - dobutamine stress echocardiography

Ref.	TP	FP	FN	TN	Total number of patients in the study	Proportion of patients who underwent ICA	Definition of patients included	Criteria for ICA indication	Lesion for definition of positive ICA	QUADAS-2 quality analysis criteria
Ibrahim et al[13]	5	8	5	22	366	10.9%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive DSE	NA	RB: P + I - R + F ? AC: P + I ? R +
Donovan et al[14]	3	6	1	8	190	9.5%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive DSE	> 50%	RB: P + I + R + F + AC: P + I + R +
Findlay et al[15]	1	6	0	0	117	6%	Cirrhotic patients in pre-LT evaluation	Transplanted patients	> 70%	RB: P + I + R + F + AC: P – I + R +
Harinstein et al[16]	2	7	14	41	105	61%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive DSE	> 70%	RB: P + I + R + F + AC: P + I + R +
Harinstein et al[16]	4	5	20	35	105	61%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive DSE	> 50%	RB: P + I + R + F + AC: P + I + R +
Plotkin et al[17]	2	0	0	19	40	52.5%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive DSE	> 70%	RB: P + I + R + F + AC: P + I + R +
Ramrakhiani et al[18]	4	10	0	0	201	7%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive DSE	> 70%	RB: P + I – R – F ? AC: P + I – R –
Tsutsui et al[19]	2	5	0	10	230	7.4%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive DSE	> 50%	RB: P + I + R + F + AC: P + I + R +
Umphrey et al[20]	0	0	0	9	157	5.7%	Cirrhotic patients in pre-LT evaluation	High risk patients	> 70%	RB: P + I + R + F + AC: P + I + R +
Snipelisky et al[21]	12	16	20	18	66	100%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive DSE	> 50%	RB: P + I + R + F + AC: P + I + R +
Patel et al[22]	15	10	56	124	420	48.8%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive DSE	> 70%	RB: P + I + R + F + AC: P + I + R +

TP: True positive; FP: False positive; FN: False negative; TN: True negative; ICA: Invasive coronary angiography; LT: Liver transplantation; DSE: Dobutamine stress echocardiography; NA: Not available; QUADAS-2: Quality assessment of diagnostic accuracy studies-2; RB: Risk of bias; P: Patient selection; I: Index text; R: Reference standard; F: Flow and timing; AC: Applicability concerns.

Table 2 Studies included for analysis - myocardial perfusion scintigraphy

Ref.	TP	FP	FN	TN	Total number of patients in the study	Proportion of patients who underwent ICA	Definition of patients included	Criteria for ICA indication	Lesion for definition of positive ICA	QUADAS-2 quality analysis criteria
Baker et al[23]	8	4	0	14	74	35.1%	Cirrhotic patients in pre-LT evaluation with cardiac risk factors	High risk patients/positive MPS	> 70%	RB: P – I + R + F + AC: P – I + R +
Kryzhanovski et al[24]	0	1	0	0	63	1.6%	Cirrhotic patients in pre-LT evaluation with cardiac risk factors	High risk patients/positive MPS	> 70%	RB: P – I + R + F + AC: P – I + R +
Senzolo et al[25]	0	2	0	0	24	8.3%	Cirrhotic patients in pre-LT evaluation	Positive MPS	> 70%	RB: P – I + R + F + AC: P – I + R +
Kandiah et al[26]	1	4	0	5	93	10.7%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive MPS	> 70%	RB: P – I + R + F + AC: P – I + R +
Oprea-Lager et al[27]	1	1	0	0	156	1.2%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive MPS	> 70%	RB: P – I + R + F + AC: P – I + R +
Davidson et al[28]	7	24	12	40	83	100%	Cirrhotic patients in pre-LT evaluation with cardiac risk factors	High risk patients/positive MPS	> 70%	RB: P + I + R + F + AC: P + I + R +
Aydinalp et al[29]	6	34	0	64	389	26.7%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive MPS	> 50%	RB: P + I + R + F + AC: P + I + R +
Zoghbi et al[30]	2	11	2	12	87	31%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive MPS	> 70%	RB: P – I + R + F + AC: P – I + R +
Bezinover et al[31]	3	1	3	9	173	9.2%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive MPS	NA	RB: P + I + R + F + AC: P + I + R +
Bhutani et al[32]	20	46	12	215	414	70.7%	Cirrhotic patients in pre-LT evaluation	High risk patients/positive MPS	> 70%	RB: P + I + R + F + AC: P + I + R +

TP: True positive; FP: False positive; FN: False negative; TN: True negative; ICA: Invasive coronary angiography; LT: Liver transplantation; MPS: Myocardial perfusion scintigraphy; NA: Not available; QUADAS-2: Quality assessment of diagnostic accuracy studies-2; RB: Risk of bias; P: Patient selection; I: Index text; R: Reference standard; F: Flow and timing; AC: Applicability concerns.