Ratio of mean platelet volume to platelet count is a potential surrogate marker predicting liver cirrhosis

Table 1 Univariate analysis of factors in non-liver cirrhosis and liver cirrhosis groups

	Non-LC group, n = 202	LC group, n = 100	P-value
Etiology
HBV	43 (21.2%)	10 (10.0%)
HCV	89 (44.1%)	72 (72.0%)
NBNC	70 (34.7%)	18 (18.0%)	< 0.001
Edmonson-Steiner grade
I	30 (30.0%)	36 (17.8%)	0.07
II	64 (64.0%)	151 (74.8%)
III	4 (4.0%)	13 (6.4%)
IV	2 (2.0%)	2 (1.0%)
PLT, × 104/μL	18.9 ± 8.1	11.6 ± 4.6	< 0.0001
MPV, fL	10.2 ± 0.9	10.8 ± 0.9	< 0.0001
MPV/PLT ratio	0.64 ± 0.30	1.10 ± 0.51	< 0.0001
PT, %	92.9 ± 11.7	82.5 ± 11.1	< 0.0001
AST, IU/L	42 ± 26	51 ± 23	< 0.0001
ALT, IU/L	40 ± 30	47 ± 33	0.02
Total-bilirubin, mg/dL	0.67 ± 0.23	0.90 ± 0.34	< 0.0001
Albumin, g/dL	3.8 ± 0.5	3.6 ± 0.4	0.01
Cholinesterase, IU/L	235 ± 80	193 ± 60	< 0.0001
Type 4 collagen, ng/mL	6.3 ± 2.4	9.1 ± 4.4	0.04
Hyaluronic acid, ng/mL	147 ± 179	312 ± 318	< 0.0001
ICGR15, %	14.1 ± 8.3	22.1 ± 12.1	< 0.0001
GSA Rmax, mg/min	0.62 ± 0.21	0.44 ± 0.17	< 0.0001

All results reported as mean ± standard deviation. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GSA-Rmax: Maximal removal rate of 99mTc-DTPA-galactosyl human serum albumin; HBV: Positive for hepatitis B antigen; HCV: Positive for hepatitis C antibody; ICGR15: Indocyanine green retention rate at 15 min; LC: Liver cirrhosis; MPV: Mean platelet volume; PLT: Platelet count; PT: Prothrombin activity.

Table 2 Multivariate analysis of factors predicting liver cirrhosis

		Odds ratio	P-value	95%CI
MPV/PLT ratio	≥ 0.71, n = 151	3.71	< 0.0001	1.94-7.28
	< 0.71, n = 151
PT, %	≥ 89.0, n = 151	2.68	0.0018	1.44-5.06
	< 89.0, n = 151
AST, IU/L	≥ 39, n = 155	3.30	0.01	1.30-9.09
	< 39, n = 147
ALT, IU/L	≥ 34, n = 153	2.57	0.04	1.02-7.09
	< 34, n = 149
Total-bilirubin, mg/dL	≥ 0.7, n = 177	1.89	0.04	1.00-3.61
	< 0.7, n = 125
Albumin, g/dL	≥ 3.8, n = 168	0.95	0.89	0.47-1.89
	< 3.8, n = 134
Cholinesterase, IU/L	≥ 211, n = 152	0.98	0.96	0.48-1.98
	< 211, n = 150
Type 4 collagen, ng/mL	≥ 6.5, n = 166	0.95	0.86	0.51-1.72
	< 6.5, n = 136
Hyaluronic acid, ng/mL	≥ 124, n = 153	2.28	0.008	1.23-4.26
	< 124, n = 149
ICGR15, %	≥ 14.3, n = 151	1.40	0.30	0.72-2.68
	< 14.3, n = 151
GSA Rmax, mg/min	≥ 0.555, n = 151	1.51	0.24	0.75-3.04
	< 0.555, n = 151

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CI: Confidence interval; GSA-Rmax: Maximal removal rate of 99mTc-DTPA-galactosyl human serum albumin; ICGR15: Indocyanine green retention rate at 15 min; MPV: Mean platelet volume; PLT: Platelet count; PT: Prothrombin activity.