Published online Jan 27, 2018. doi: 10.4254/wjh.v10.i1.82
Peer-review started: March 28, 2017
First decision: June 30, 2017
Revised: November 10, 2017
Accepted: December 4, 2017
Article in press: December 7, 2017
Published online: January 27, 2018
Processing time: 305 Days and 23.2 Hours
Several noninvasive methods for predicting cirrhosis have been reported, but liver biopsy is the only method for obtaining a definitive diagnosis. However, liver biopsy is invasive, and a noninvasive diagnostic method is desirable. Mean platelet volume (MPV), the size of platelets, can be determined from routine complete blood count data of blood samples. Generally, if bone marrow hematopoietic function decreases, MPV decreases. In contrast, if spleen function increases, new platelets are made rapidly and MPV increases. In recent years, the relationship between MPV and liver disease has attracted attention.
There are reports that MPV correlates with liver function, and there are reports that MPV is related to the incidence of HCC. However, there is no report to evaluate the correlation between MPV/platelet count (PLT) and liver function, so we undertook this study.
The authors studied only patients who were diagnosed with cirrhosis histopathologically after liver resection. The MVP/PLT ratio could predict cirrhosis more sensitively than other general liver function tests.
The MPV/PLT ratio also correlated with the degree of hepatic fibrosis according to the Inuyama classification. The authors examined the relationship between prognosis after hepatic resection of hepatocellular carcinoma and the value of the MPV/PLT ration, but unfortunately no correlation was found.
MPV is the size of platelets and can be determined from routine complete blood count data of blood samples. Liver cirrhosis and fibrosis are related to MPV.