Adipokine profiles reflect metabolic dysfunction but not fibrosis in patients with primary biliary cholangitis

Figure 1 Receiver operating characteristic curve. A: Receiver operating characteristic curve showing the discriminative ability of the log-transformed leptin/adiponectin ratio for detecting metabolic dysfunction-associated steatotic liver disease in primary biliary cholangitis patients. Area under the curve (AUC) = 0.853, 95% confidence interval: 0.770-0.937, P < 0.001. The AUC was 0.853, indicating high diagnostic accuracy of the leptin/adiponectin ratio for identifying metabolic dysfunction-associated steatotic liver disease; B: Receiver operating characteristic curve evaluating the ability of the log-transformed leptin/adiponectin ratio to discriminate the presence of metabolic syndrome in patients with primary biliary cholangitis. AUC = 0.689, 95% confidence interval: 0.573-0.824, P = 0.003. The leptin/adiponectin ratio yielded an AUC of 0.689, suggesting moderate-to-high discriminative ability for metabolic syndrome. ROC: Receiver operating characteristic.

Figure 2 Receiver operating characteristic curve assessing the performance of the log-transformed leptin/adiponectin ratio in predicting advanced liver fibrosis among primary biliary cholangitis patients. Area under the curve = 0.589; 95% confidence interval: 0.442-0.737; P = 0.242. ROC: Receiver operating characteristic.