Ide R, Oshita A, Nishisaka T, Nakahara H, Aimitsu S, Itamoto T. Primary biliary cholangitis metachronously complicated with combined hepatocellular carcinoma-cholangiocellular carcinoma and hepatocellular carcinoma. World J Hepatol 2017; 9(36): 1378-1384 [PMID: 29359023 DOI: 10.4254/wjh.v9.i36.1378]
Corresponding Author of This Article
Akihiko Oshita, MD, PhD, Department of Gastroenterological Surgery, Hiroshima Prefectural Hospital, 1-5-54 Ujina-kanda, Minami-ku, Hiroshima 734-8530, Japan. oshita-akihiko@umin.ac.jp
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ryuta Ide, Akihiko Oshita, Hideki Nakahara, Toshiyuki Itamoto, Department of Gastroenterological Surgery, Hiroshima Prefectural Hospital, Hiroshima 734-8530, Japan
Akihiko Oshita, Toshiyuki Itamoto, Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan
Takashi Nishisaka, Department of Pathology Clinical Laboratory, Hiroshima Prefectural Hospital, Hiroshima 734-8530, Japan
Shiomi Aimitsu, Department of Hepatology, Hiroshima General Hospital of West Japan Railway Company, Hiroshima 732-0057, Japan
Author contributions: Ide R and Oshita A made conception and design of this case report; authors other than Ide R and Oshita A, Nishisaka T, Nakahara H, Aimitsu S and Itamoto T contributed to collection and interpretation of data; Ide R and Oshita A wrote the draft manuscript, and other authors performed critical revision of the manuscript; all authors gave final approval of the version to be published; Oshita A has overall responsibility and guarantees the scientific integrity.
Informed consent statement: The patient provided informed consent for the publication of this manuscript and accompanying images.
Conflict-of-interest statement: The authors have no conflict-of-interest to disclose concerning this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Akihiko Oshita, MD, PhD, Department of Gastroenterological Surgery, Hiroshima Prefectural Hospital, 1-5-54 Ujina-kanda, Minami-ku, Hiroshima 734-8530, Japan. oshita-akihiko@umin.ac.jp
Telephone: +81-82-2541818 Fax: +81-82-2526932
Received: June 17, 2017 Peer-review started: June 19, 2017 First decision: July 20, 2017 Revised: November 8, 2017 Accepted: November 19, 2017 Article in press: November 20, 2017 Published online: December 28, 2017 Processing time: 192 Days and 12 Hours
Core Tip
Core tip: Primary biliary cholangitis (PBC) is a progressive cholestatic liver disease characterized by the presence of highly specific antimitochondrial antibodies, portal inflammation and lymphocyte-dominated destruction of the intrahepatic bile ducts, which leads to cirrhosis. While its pathogenesis remains unclear, PBC that shows histological progression to fibrosis carries a high risk of carcinogenesis; the same is true of viral liver diseases. In patients with PBC, the development of hepatocellular carcinoma is rare; the development of combined hepatocellular carcinoma and cholangiocellular carcinoma (cHCC-CCC) is extraordinary. Herein, we report a rare case of PBC metachronously complicated by cHCC-CCC and HCC, which, to the best of our knowledge, has never been reported.
