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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 18, 2017; 9(35): 1286-1295
Published online Dec 18, 2017. doi: 10.4254/wjh.v9.i35.1286
Published online Dec 18, 2017. doi: 10.4254/wjh.v9.i35.1286
Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma
Hiroki Koga, Koutaro Yamaji, Takao Ide, Junji Ueda, Hirokazu Noshiro, Department of Surgery, Saga University Faculty of Medicine, Saga 849-8501, Japan
Keita Kai, Shinichi Aishima, Department of Pathology, Saga University Hospital, Saga 849-8501, Japan
Shinichi Aishima, Koutaro Yamaji, Department of Pathology and Microbiology, Saga University Faculty of Medicine, Saga 849-8501, Japan
Atsushi Kawaguchi, Center for Comprehensive Community Medicine, Saga University Faculty of Medicine, Saga 849-8501, Japan
Author contributions: Koga H is the main author of this article and performed the data correction and statistical analyzes; Kai K designed the study and conducted the data collection and contributed to the statistical analyses and the writing of the manuscript; Aishima S performed the pathological work and reviewed the manuscript; Kawaguchi A supervised the statistical analyses; Yamaji K, Ide T and Ueda J contributed to the data collection; Noshiro H contributed to the data collection and review the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: The study protocol was approved by the Ethics Committee of the Faculty of Medicine at Saga University.
Informed consent statement: Informed consent for the use of resected tissue and medical information was obtained from all patients.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Keita Kai, MD, PhD, Associate Professor, Department of Pathology, Saga University Hospital, Nabeshima 5-1-1, Saga City, Saga 849-8501, Japan. kaikeit@cc.saga-u.ac.jp
Telephone: +81-952-343264 Fax: +81-952-342055
Received: July 18, 2017
Peer-review started: July 20, 2017
First decision: September 7, 2017
Revised: September 19, 2017
Accepted: October 30, 2017
Article in press: October 30, 2017
Published online: December 18, 2017
Processing time: 141 Days and 18.2 Hours
Peer-review started: July 20, 2017
First decision: September 7, 2017
Revised: September 19, 2017
Accepted: October 30, 2017
Article in press: October 30, 2017
Published online: December 18, 2017
Processing time: 141 Days and 18.2 Hours
Core Tip
Core tip: We analyzed the occult hepatitis B virus infection (OBI) status of 78 cases of non-B, non-C hepatocellular carcinoma (NBNC HCC). OBI was found in 27/78 patients (34.6%). The OBI patients were significantly younger than the non-OBI patients at the time of surgery, and the OBI cases were frequently overlapped with other etiologies. OBI had no impact on surgical outcomes. Only tumor-related factors affected the surgical outcomes. The surgical outcomes of NBNC HCC thus depend in part on the early detection of the tumor.