Bale G, Steffie AU, Ravi Kanth VV, Rao PN, Sharma M, Sasikala M, Reddy DN. Regional differences in genetic susceptibility to non-alcoholic liver disease in two distinct Indian ethnicities. World J Hepatol 2017; 9(26): 1101-1107 [PMID: 28989566 DOI: 10.4254/wjh.v9.i26.1101]
Corresponding Author of This Article
Dr. Vishnubhotla Venkata Ravi Kanth, Group Leader-Genetics, Asian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad 500082, Telangana, India. drravikanth@aigindia.net
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Govardhan Bale, Avanthi Urmila Steffie, Vishnubhotla Venkata Ravi Kanth, Mitnala Sasikala, Asian Healthcare Foundation, Hyderabad 500082, Telangana, India
Padaki Nagaraja Rao, Mithun Sharma, Duvvur Nageshwar Reddy, Asian Institute of Gastroenterology, Hyderabad 500082, India
Author contributions: Bale G and Steffie AU performed research; Rao PN, Sharma M and Reddy DN recruited patients; Ravi Kanth VV, Sasikala M and Rao PN designed the research; Ravi Kanth VV monitored the study, performed statistical analyses, and drafted the manuscript.
Institutional review board statement: The study was reviewed and approved by Institutional review (Scientific) board (AIG/AHF IRB: 16/2014) of Asian Institute of Gastroenterology.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None to declare.
Data sharing statement: No additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Vishnubhotla Venkata Ravi Kanth, Group Leader-Genetics, Asian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad 500082, Telangana, India. drravikanth@aigindia.net
Telephone: +91-40-23378888 Fax: +91-40-23324255
Received: April 27, 2017 Peer-review started: April 28, 2017 First decision: May 23, 2017 Revised: June 29, 2017 Accepted: July 7, 2017 Article in press: July 10, 2017 Published online: September 18, 2017 Processing time: 140 Days and 13.1 Hours
Core Tip
Core tip: Non-alcoholic fatty liver disease has become the leading cause of liver damage contributing to considerable mortality. The spectrum spans from simple steatosis, through non alcoholic steatohepatitis, fibrosis, cirrhosis and finally to hepatocellular carcinoma. Genetic variants have now been recognized to contribute to a substantial extent to the onset of the disease. Reliable genetic markers that confer susceptibility to the disease have to be identified for better management of the disease. Identification of at risk individuals at a younger age by screening for genetic susceptibility will aid in better management by early interventions and lifestyle changes. This study identified regional differences and ethnicity based genetic susceptibility for non-alcoholic liver disease.
