Le Grazie M, Biagini MR, Tarocchi M, Polvani S, Galli A. Chemotherapy for hepatocellular carcinoma: The present and the future. World J Hepatol 2017; 9(21): 907-920 [PMID: 28824742 DOI: 10.4254/wjh.v9.i21.907]
Corresponding Author of This Article
Andrea Galli, MD, PhD, Gastroenterology Research Unit, Department of Experimental and Clinical Biochemical Sciences “Mario Serio”, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. a.galli@dfc.unifi.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jul 28, 2017; 9(21): 907-920 Published online Jul 28, 2017. doi: 10.4254/wjh.v9.i21.907
Chemotherapy for hepatocellular carcinoma: The present and the future
Marco Le Grazie, Maria Rosa Biagini, Mirko Tarocchi, Simone Polvani, Andrea Galli
Marco Le Grazie, Maria Rosa Biagini, Mirko Tarocchi, Simone Polvani, Andrea Galli, Gastroenterology Research Unit, Department of Experimental and Clinical Biochemical Sciences “Mario Serio”, University of Florence, 50139 Florence, Italy
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: The authors declare no potential conflicts of interest or financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Andrea Galli, MD, PhD, Gastroenterology Research Unit, Department of Experimental and Clinical Biochemical Sciences “Mario Serio”, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. a.galli@dfc.unifi.it
Telephone: +39-55-2758115 Fax: +39-55-2758411
Received: April 12, 2017 Peer-review started: April 12, 2017 First decision: May 19, 2017 Revised: June 13, 2017 Accepted: June 30, 2017 Article in press: July 3, 2017 Published online: July 28, 2017 Processing time: 104 Days and 9.7 Hours
Core Tip
Core tip: The aim of this review is to make a point on chemotherapeutic options for treatment of hepatocellular carcinoma (HCC) at advanced stage, the most frequent stage of presentation of this neoplasia, still characterized by an important mortality rate. By now, sorafenib is the only standard treatment, but other options were recently studied and will be soon available for clinicians and patients affected by HCC. The review can be divided in four sections: The first one regards molecular target therapy and are described sorafenib, its open issues, but also other drugs with similar targets that have been evaluated for treatment of HCC. The second and the third parts regard cytotoxic drugs and immunotherapy, respectively, which were evaluated in recent years as possible alternatives or adjuvant to Sorafenib. In the last part of the review, future perspectives are described, in particular for what concerns resistance mechanism of the neoplasia, delivery methods or biological enhancers for drugs already in use, new drugs that will be probably evaluated and molecular targets that could soon become eligible for target therapy hopefully leading to the development of personalized therapy.
