©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 18, 2017; 9(11): 533-543
Published online Apr 18, 2017. doi: 10.4254/wjh.v9.i11.533
Published online Apr 18, 2017. doi: 10.4254/wjh.v9.i11.533
Hepatocellular carcinoma in non-alcoholic steatohepatitis: Current knowledge and implications for management
George Cholankeril, Sanjaya K Satapathy, Division of Gastroenterology and Hepatology, Methodist University Hospital Transplant Institute, University of Tennessee Health Sciences Center, Memphis, TN 38104, United States
Ronak Patel, Department of Medicine, University of Alabama at Birmingham, Montgomery Health Center, Montgomery, AL 36116, United States
Sandeep Khurana, Division of Gastroenterology, Georgia Regents University, Augusta, GA 30912, United States
Author contributions: Cholankeril G was responsible for drafting the article, critical revision of the article and approval of the article; Patel R was responsible for drafting the article, critical revision of the article and approval of the article; Khurana S was responsible for critical revision of the article, intellectual input, and approval of the article; Satapathy SK was responsible for the concept/design, drafting the article, critical revision of the article and approval of the article.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose related to the research or data presented in this manuscript. There was no funding for this study. This manuscript is not being considered for publication elsewhere.
Correspondence to: Sanjaya K Satapathy, MBBS, MD, DM, FACG, FASGE, Associate Professor of Surgery Transplant Hepatologist, Division of Gastroenterology and Hepatology, Methodist University Hospital Transplant Institute, University of Tennessee Health Sciences Center, 1211 Union Avenue, Suite 340, Memphis, TN 38104, United States. ssatapat@uthsc.edu
Telephone: +1-901-5169179 Fax: +1-901-5168993
Received: July 29, 2016
Peer-review started: July 31, 2016
First decision: September 8, 2016
Revised: February 25, 2017
Accepted: March 14, 2017
Article in press: March 14, 2017
Published online: April 18, 2017
Processing time: 258 Days and 3.1 Hours
Peer-review started: July 31, 2016
First decision: September 8, 2016
Revised: February 25, 2017
Accepted: March 14, 2017
Article in press: March 14, 2017
Published online: April 18, 2017
Processing time: 258 Days and 3.1 Hours
Core Tip
Core tip: Non-alcoholic steatohepatitis (NASH) is anticipated to account for a greater proportion of hepatocellular carcinoma (HCC) incidence due to the growing epidemic of obesity and diabetes. Currently NASH-related HCC is the fastest growing indication for liver transplant in HCC candidates. Increased efforts to implement effective screening and preventative strategies particularly in non-cirrhotic NASH patients possibly based on genetic susceptibility are needed to reduce the future impact imposed by NASH-related HCC.