©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 28, 2016; 8(3): 162-182
Published online Jan 28, 2016. doi: 10.4254/wjh.v8.i3.162
Published online Jan 28, 2016. doi: 10.4254/wjh.v8.i3.162
Innate immunity and hepatocarcinoma: Can toll-like receptors open the door to oncogenesis?
Jorge André Gomes Lopes, Marta Borges-Canha, Pedro Pimentel-Nunes, Department of Physiology and Cardiothoracic Surgery, Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
Pedro Pimentel-Nunes, Gastroenterology Department, Portuguese Oncology Institute, 4200-072 Porto, Portugal
Pedro Pimentel-Nunes, CINTESIS/Department of Biostatistics and Medical Informatics, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
Author contributions: Pimentel-Nunes P and Borges-Canha M designed the methodology followed; Lopes JAG performed the research and analysed the data; Lopes JAG and Borges-Canha M wrote the paper; Borges-Canha M and Pimentel-Nunes P made critical revisions to the paper.
Conflict-of-interest statement: All the authors certify that they have no conflict of interest.
Correspondence to: Pedro Pimentel-Nunes, Professor, Department of Physiology and Cardiothoracic Surgery, Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. pedronunesml@gmail.com
Telephone: +351-96-7340096 Fax: +351-22-5513601
Received: June 28, 2015
Peer-review started: July 11, 2015
First decision: August 16, 2015
Revised: November 15, 2015
Accepted: December 4, 2015
Article in press: December 8, 2015
Published online: January 28, 2016
Processing time: 207 Days and 1.4 Hours
Peer-review started: July 11, 2015
First decision: August 16, 2015
Revised: November 15, 2015
Accepted: December 4, 2015
Article in press: December 8, 2015
Published online: January 28, 2016
Processing time: 207 Days and 1.4 Hours
Core Tip
Core tip: The importance of hepatocarcinoma (HCC) is undeniable in the current medical perspective. However, a lot still remains to be understood in this context. Therefore, this review aims to present the significance of innate immunity in HCC through toll-like receptors as they have already shown interesting effects on tumour’s microenvironment, influencing its progression or regression. As a result we also render some therapeutic usages of the established knowledge in this area.