©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 28, 2016; 8(27): 1119-1127
Published online Sep 28, 2016. doi: 10.4254/wjh.v8.i27.1119
Published online Sep 28, 2016. doi: 10.4254/wjh.v8.i27.1119
Molecular pathological epidemiology in diabetes mellitus and risk of hepatocellular carcinoma
Chun Gao, Department of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, China
Author contributions: Gao C conceived the topic, performed research, retrieved concerned literatures and wrote the paper.
Supported by Beijing NOVA Programme of Beijing Municipal Science and Technology Commission , No. Z13110.7000413067 .
Conflict-of-interest statement: No conflict of interest.
Correspondence to: Chun Gao, MD, Department of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, No. 2 Yinghua East Road, Beijing 100029, China. gaochun@bjmu.edu.cn
Telephone: +86-10-84205313 Fax: +86-10-64481924
Received: April 2, 2016
Peer-review started: April 7, 2016
First decision: June 6, 2016
Revised: June 28, 2016
Accepted: August 6, 2016
Article in press: August 8, 2016
Published online: September 28, 2016
Processing time: 172 Days and 17.7 Hours
Peer-review started: April 7, 2016
First decision: June 6, 2016
Revised: June 28, 2016
Accepted: August 6, 2016
Article in press: August 8, 2016
Published online: September 28, 2016
Processing time: 172 Days and 17.7 Hours
Core Tip
Core tip: Diabetes mellitus (DM) is an established independent risk factor for hepatocellular carcinoma (HCC); however, how DM affects the occurrence and development of HCC remains as yet unclearly understood. Molecular pathological epidemiology (MPE) may be a promising approach to investigate the molecular mechanisms of carcinogenesis of DM in HCC, and provide some useful insights for this pathological process. This review highlights the recent advances in this field and more MPE studies are expected to be performed for this question in future.