Mathew S, Faheem M, Ibrahim SM, Iqbal W, Rauff B, Fatima K, Qadri I. Hepatitis C virus and neurological damage. World J Hepatol 2016; 8(12): 545-556 [PMID: 27134702 DOI: 10.4254/wjh.v8.i12.545]
Corresponding Author of This Article
Ishtiaq Qadri, Professor, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. ishtiaq80262@yahoo.com
Research Domain of This Article
Virology
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Review
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Mathew S, Faheem M, Ibrahim SM, Iqbal W, Rauff B, Fatima K, Qadri I. Hepatitis C virus and neurological damage. World J Hepatol 2016; 8(12): 545-556 [PMID: 27134702 DOI: 10.4254/wjh.v8.i12.545]
World J Hepatol. Apr 28, 2016; 8(12): 545-556 Published online Apr 28, 2016. doi: 10.4254/wjh.v8.i12.545
Hepatitis C virus and neurological damage
Shilu Mathew, Muhammed Faheem, Sara M Ibrahim, Waqas Iqbal, Bisma Rauff, Kaneez Fatima, Ishtiaq Qadri
Shilu Mathew, Muhammed Faheem, Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Muhammed Faheem, Department of Biosciences, Faculty of Sciences, COMSATS Institute of Information Technology, Islamabad 45550, Pakistan
Sara M Ibrahim, Waqas Iqbal, Department of Biochemistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Bisma Rauff, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, NSW 2006, Australia
Kaneez Fatima, IQ Institute of Infection and Immunity, Lahore 54000, Pakistan
Ishtiaq Qadri, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Author contributions: Mathew S and Faheem M contributed equally to this manuscript; Qadri I conceived and designed the topic; Mathew S, Faheem M, Ibrahim SM, Iqbal W and Rauff B contributed to materials and wrote the paper; Faheem M, Ibrahim SM, Iqbal W, Rauff B, Fatima K and Qadri I contributed to proof reading of the manuscript.
Supported by KACST large R and D grant to Ishtiaq Qadri (#162-34).
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Correspondence to: Ishtiaq Qadri, Professor, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. ishtiaq80262@yahoo.com
Received: August 27, 2015 Peer-review started: August 31, 2015 First decision: October 8, 2015 Revised: March 19, 2016 Accepted: April 7, 2016 Article in press: April 11, 2016 Published online: April 28, 2016 Processing time: 236 Days and 10.5 Hours
Core Tip
Core tip: There is high prevalence rate of neuropsychiatric ailments with respect to patients infected with chronic hepatitis C virus (HCV). Brain inflammatory disorders, cerebrovascular disease peripheral neuropathy, psychiatric disturbs and cognitive symptoms are the complex clinical signs which occurs when infected by chronic HCV infection. HCV prompts psychiatric and neurological symptoms through numerous pathways with imprecise mechanisms, which includes neurotransmitter and metabolic pathway imbalance, immune-mediated responses and direct brain neurotoxicity inflammation. Awareness of HCV-associated neuropsychiatric disorders and its pathogenic mechanisms is vital to understand the clinical manifestations and to introduce an applicable treatment.
