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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 28, 2016; 8(12): 533-544
Published online Apr 28, 2016. doi: 10.4254/wjh.v8.i12.533
Published online Apr 28, 2016. doi: 10.4254/wjh.v8.i12.533
Incidence, risk factors and outcomes of de novo malignancies post liver transplantation
Pavan Kedar Mukthinuthalapati, Raghavender Gotur, Marwan Ghabril, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Author contributions: Mukthinuthalapati PK interpretation of literature, drafting and final approval of the article; Gotur R interpretation of literature, drafting and final approval of the article; Ghabril M interpretation of literature, drafting and final approval of the article.
Conflict-of-interest statement: All the authors have no conflicts to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Marwan Ghabril, MD, Associate Professor of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 702 Rotary Circle 225, Indianapolis, IN 46202, United States. mghabril@iu.edu
Telephone: +1-317-2781630 Fax: +1-317-2786870
Received: January 9, 2016
Peer-review started: January 10, 2016
First decision: February 22, 2016
Revised: March 8, 2016
Accepted: April 5, 2016
Article in press: April 6, 2016
Published online: April 28, 2016
Processing time: 100 Days and 17.6 Hours
Peer-review started: January 10, 2016
First decision: February 22, 2016
Revised: March 8, 2016
Accepted: April 5, 2016
Article in press: April 6, 2016
Published online: April 28, 2016
Processing time: 100 Days and 17.6 Hours
Core Tip
Core tip: The risk of new cancers is significantly increased after liver transplantation (LT), and is driven by patient factors, oncogenic viruses and lifelong immunosuppression. De novo malignancy is a major risk factor for mortality after LT, equaling the risk of cardiovascular disease or infectious diseases. The risk of de novo malignancies may be reduced by attention to patient risk factors and minimization of immunosuppression when possible. Ultimately rigorous surveillance is needed to allow for early diagnosis and attenuation of mortality risk.