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Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. May 28, 2015; 7(9): 1282-1286
Published online May 28, 2015. doi: 10.4254/wjh.v7.i9.1282
Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinoma
Xin Zhang, Hui-Guo Ding
Xin Zhang, Hui-Guo Ding, Department of Gastroenterology and Hepatology, Beijing You’an Hospital affiliated with Capital Medical University, Beijing 100069, China
Author contributions: Zhang X contributed to the data collection and preparing the manuscript; Ding HG was responsible for this project and the final manuscript.
Supported by The Capital Science and Technology Development Foundation, Major Projects on Infectious Disease, No. 2012ZX1002-008-05; High-Level Talent Academic Leader Training Program, No. 2011-2-19; Capital Science and Tchnology Development Fund, No. 2014-1-2181.
Conflict-of-interest: The authors have no other financial interests or conflict with the subject or materials and results in the manuscript apart from those disclosed.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hui-Guo Ding, MD, PhD, Director of Gastroenterology and Hepatology, Department of Gastroenterology and Hepatology, Beijing You’an Hospital affiliated with Capital Medical University, Fengtai District, Beijing 100069, China. dinghuiguo@medmail.com.cn
Telephone: +86-10-83997155 Fax: +86-10-63295525
Received: November 28, 2014
Peer-review started: November 28, 2014
First decision: January 8, 2015
Revised: January 19, 2015
Accepted: March 16, 2015
Article in press: March 18, 2015
Published online: May 28, 2015
Processing time: 172 Days and 23.1 Hours
Core Tip

Core tip: This mini review fully describes the relationship between hepatitis B virus (HBV) genome mutations in different regions with liver disease progression and development to hepatocellular carcinoma (HCC) according to the recent data of mutations in chronic hepatitis B patients. Accordingly, the HBV mutations, either in the preS or PreC or/and core promoter region, are significantly associated with HCC and could be regarded as a biomarker to predict the occurrence of HCC.