Hepatocellular carcinoma: From clinical practice to evidence-based treatment protocols

doi:10.4254/wjh.v7.i20.2274

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Sep 18, 2015; 7(20): 2274-2291
Published online Sep 18, 2015. doi: 10.4254/wjh.v7.i20.2274

Hepatocellular carcinoma: From clinical practice to evidence-based treatment protocols

Danijel Galun, Dragan Basaric, Marinko Zuvela, Predrag Bulajic, Aleksandar Bogdanovic, Nemanja Bidzic, Miroslav Milicevic

Danijel Galun, Dragan Basaric, Marinko Zuvela, Predrag Bulajic, Aleksandar Bogdanovic, Nemanja Bidzic, Miroslav Milicevic, Clinic of Digestive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia

Danijel Galun, Marinko Zuvela, Miroslav Milicevic, Medical School, University of Belgrade, 11000 Belgrade, Serbia

Author contributions: Galun D and Milicevic M designed research; Galun D, Basaric D and Zuvela M performed research; Bulajic P, Bogdanovic A and Bidzic N analyzed data; Galun D and Milicevic M wrote the paper.

Conflict-of-interest statement: The authors state no conflict of interest.

Correspondence to: Danijel Galun, Associate Professor, Clinic of Digestive Surgery, University Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade, Serbia. galun95@gmail.com

Telephone: +381-11-3615652 Fax: +381-11-3615655

Received: August 29, 2014
Peer-review started: August 30, 2014
First decision: November 14, 2014
Revised: July 6, 2015
Accepted: August 30, 2015
Article in press: August 31, 2015
Published online: September 18, 2015
Processing time: 382 Days and 13.3 Hours

Core Tip

Core tip: In response to the hepatocellular carcinoma (HCC) burden marked differences between countries are reflected in providing disparate quality of healthcare considering screening and surveillance programs; available treatment modalities and drugs; reimbursement of specific treatment options by the state-funded health insurance. Since the number of new HCC cases being diagnosed each year is nearly equal to the number of deaths from this cancer it is clear that the international scientific community and healthcare systems worldwide have no efficient answer to this problem. International consensus on the use of any given staging model is lacking. High-quality trials with better patients’ stratification are mandatory. This review article reflects the perspective of liver surgeons working in a developing country.