MicroRNAs dysregulation in hepatocellular carcinoma: Insights in genomic medicine

doi:10.4254/wjh.v7.i11.1530

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World Journal of Hepatology

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World J Hepatol. Jun 18, 2015; 7(11): 1530-1540
Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1530

MicroRNAs dysregulation in hepatocellular carcinoma: Insights in genomic medicine

Iván Lyra-González, Laura E Flores-Fong, Ignacio González-García, David Medina-Preciado, Juan Armendáriz-Borunda

Iván Lyra-González, Laura E Flores-Fong, Ignacio González-García, David Medina-Preciado, Juan Armendáriz-Borunda, Departamento de Biología Molecular y Genómica, CUCS, Universidad de Guadalajara, Instituto de Biología Molecular en Medicina y Terapia Génica, Guadalajara, Jalisco 44281, México

Ignacio González-García, O.P.D. Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara, Jalisco 44281, México

David Medina-Preciado, O.P.D. Hospital Civil de Guadalajara “Juan I. Menchaca”, Guadalajara, Jalisco 44281, México

Juan Armendáriz-Borunda, Departamento de Biología Molecular y Genómica, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco 44281, México

Author contributions: All the authors equally contributed to this work.

Conflict-of-interest: Authors have no conflict of interests related to this manuscript. All authors have contributed equally in the realization of this manuscript.

Correspondence to: Dr. Juan Armendariz-Borunda, PhD, Head, Departamento de Biología Molecular y Genómica, CUCS, Universidad de Guadalajara, Sierra Mojada # 950, Guadalajara, Jalisco 44281, Mexico. armdbo@gmail.com

Telephone: +52-33-10585317 Fax: +52-33-10585318

Received: September 17, 2014
Peer-review started: September 20, 2014
First decision: November 27, 2014
Revised: December 22, 2014
Accepted: May 8, 2015
Article in press: May 11, 2015
Published online: June 18, 2015
Processing time: 272 Days and 2.7 Hours

Core Tip

Core tip: MicroRNAs are implicated in the control of gene expression which enable them a relevant new target for diagnosis, prognosis and treatment in a wide variety of pathologic entities, including hepatocellular carcinoma (HCC). This manuscript represents an attempt to summarize current knowledge regarding miRNAs and their role in HCC development.

Lyra-González I, Flores-Fong LE, González-García I, Medina-Preciado D, Armendáriz-Borunda J. MicroRNAs dysregulation in hepatocellular carcinoma: Insights in genomic medicine. World J Hepatol 2015; 7(11): 1530-1540 [PMID: 26085912 DOI: 10.4254/wjh.v7.i11.1530]

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