©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 8, 2015; 7(10): 1369-1376
Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1369
Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1369
Non-alcoholic fatty liver disease - the heart of the matter
Haneen Azzam, Stephen Malnick, Department of Internal Medicine C, Kaplan Medical Center, Rehovot 76100, Israel
Author contributions: Both Azzam H and Malnick S contributed equally to the planning and writing of this manuscript.
Conflict-of-interest: The authors have no conflicts of interest to declare.
Correspondence to: Stephen Malnick, MA, MSc MBBS, Department of Internal Medicine C, Kaplan Medical Center, Pasternak St., P.O.B 1, Rehovot 76100, Israel. stephen@malnick.net
Telephone: +97-28-9441371 Fax: +97-28-9441852
Received: December 21, 2014
Peer-review started: December 21, 2014
First decision: January 20, 2015
Revised: March 2, 2015
Accepted: March 30, 2015
Article in press: April 2, 2015
Published online: June 8, 2015
Processing time: 164 Days and 7.2 Hours
Peer-review started: December 21, 2014
First decision: January 20, 2015
Revised: March 2, 2015
Accepted: March 30, 2015
Article in press: April 2, 2015
Published online: June 8, 2015
Processing time: 164 Days and 7.2 Hours
Core Tip
Core tip: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Due to the overlapping cardiovascular risk factors in the metabolic syndrome, there are cardiovascular consequences linked to the presence of NAFLD in a patient. We review these complications and also a less well appreciated complication of diastolic dysfunction that is intimately associated with NAFLD. Physicians looking after NAFLD patients need to be aware of these complications and actively search for and treat them.