Murine model to study brain, behavior and immunity during hepatic encephalopathy

doi:10.4254/wjh.v6.i4.243

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Apr 27, 2014; 6(4): 243-250
Published online Apr 27, 2014. doi: 10.4254/wjh.v6.i4.243

Murine model to study brain, behavior and immunity during hepatic encephalopathy

Gustavo Batista Menezes, Antonio Lúcio Teixeira, Márcio Flávio Moraes, Mauro Martins Teixeira, Remo Castro Russo, Anderson José Ferreira, Marco Antônio Peliky Fontes, Fabiana Paiva Martins, Fabíola Mara Ribeiro, Giselle Foureaux, Patricia Alves Maia Guidine, Gustavo Henrique Souza Resende, Thais Reis Lage, Sylvia Stella Amaral, Rafaela Vaz Pereira, Bruno Engler Faleiros, Pedro Elias Marques, Lindisley Ferreira Gomides

Lindisley Ferreira Gomides, Pedro Elias Marques, Rafaela Vaz Pereira, Sylvia Stella Amaral, Thais Reis Lage, Gustavo Batista Menezes, Laboratório de Imunobiofotônica, Department of Morphology, ICB, UFMG, Belo Horizonte 31270-901, Brazil

Bruno Engler Faleiros, Fabiana Paiva Martins, Antonio Lúcio Teixeira, School of Medicine, UFMG, Belo Horizonte 31270-901, Brazil

Gustavo Henrique Souza Resende, Patricia Alves Maia Guidine, Marco Antônio Peliky Fontes, Remo Castro Russo, Márcio Flávio Moraes, Department of Physiology, ICB, UFMG, Belo Horizonte 31270-901, Brazil

Giselle Foureaux, Anderson José Ferreira, Department of Morphology, UFMG, Belo Horizonte 31270-901, Brazil

Fabíola Mara Ribeiro, Mauro Martins Teixeira, Department of Biochemistry and Immunology, UFMG, Belo Horizonte 31270-901, Brazil

Author contributions: Gomides LF, Marques PE, Faleiros BE, Pereira RV, Amaral SS, Lage TR, Resende GHS, Guidine PAM, Foureaux G, Ribeiro FM and Martins FP performed the majority of experiments and analyzed data; Fontes MAP, Ferreira AJ, Russo RC, Teixeira MM, Moraes MF and Teixeira AL performed experiments and interpreted results; Menezes GB designed the study and wrote the manuscript; Gomides LF, Marques PE and Menezes GB revised the manuscript; all authors approved the final version to be published.

Correspondence to: Gustavo Batista Menezes, PhD, Laboratório de Imunobiofotônica, Department of Morphology, ICB, UFMG, Av. Antonio Carlos, 6627 - Pampulha, Belo Horizonte 31270-901, Brazil. menezesgb@ufmg.br

Telephone: +55-31-34093015 Fax: +55-31-34093015

Received: November 21, 2013
Revised: January 17, 2014
Accepted: February 16, 2014
Published online: April 27, 2014
Processing time: 180 Days and 14.6 Hours

Core Tip

Core tip: The study of hepatic encephalopathy is crucial for development of new therapies but has been dampened by the absence of murine models resembling the disease in patients. We showed that sequential thioacetamide injections cause extensive liver injury in mice, leading to increased ammonia levels, electroencephalography alterations and brain edema. In line with this, mice presented with poor psychomotor activity and survival rate. Liver injury and brain function impairment by thioacetamide resulted in systemic alterations such as coagulopathy, hemodynamic instability and lung inflammation, consistent with multiple organ failure. Therefore, this alternative model may provide tools for new therapeutic insights for hepatic encephalopathy.