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World J Hepatol. Sep 27, 2013; 5(9): 513-520
Published online Sep 27, 2013. doi: 10.4254/wjh.v5.i9.513
Published online Sep 27, 2013. doi: 10.4254/wjh.v5.i9.513
Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia
Rikke Hebo Larsen, Mette S Kjær, Martin Eefsen, Fin Stolze Larsen, Peter Nissen Bjerring, Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, 2100 Copenhagen, Denmark
Author contributions: All the authors contributed to this manuscript.
Correspondence to: Peter Nissen Bjerring, PhD, Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark. peterbjerring@gmail.com
Telephone: +45-28-976095 Fax: +45-35-452913
Received: April 5, 2013
Revised: June 8, 2013
Accepted: August 20, 2013
Published online: September 27, 2013
Processing time: 179 Days and 13.2 Hours
Revised: June 8, 2013
Accepted: August 20, 2013
Published online: September 27, 2013
Processing time: 179 Days and 13.2 Hours
Core Tip
Core tip: Acute liver failure and hyperammonaemia can lead to severe brain oedema. Preserving mitochondrial function by treatment with ciclosporin has shown potential in in vitro studies. In this study we evaluated the effect of ciclosporin in a rat model of acute hyperammonaemia on intracranial pressure, brain water content and expression of the water channel aquaporin-4. We did not find a beneficial effect of ciclosporin on intracranial pressure, brain water content or aquaporin-4 expression.