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World J Hepatol. Jun 27, 2013; 5(6): 340-344
Published online Jun 27, 2013. doi: 10.4254/wjh.v5.i6.340
Published online Jun 27, 2013. doi: 10.4254/wjh.v5.i6.340
Multiple focal nodular hyperplasias induced by oxaliplatin-based chemotherapy
Matteo Donadon, Guido Torzilli, Liver Surgery Unit, Department of General Surgery, University of Milan, Humanitas Clinical and Research Center, 20089 Rozzano, Milan, Italy
Luca Di Tommaso, Massimo Roncalli, Department of Pathology, University of Milan, Humanitas Clinical and Research Center, 20089 Rozzano, Milan, Italy
Author contributions: Donadon M designed and wrote the manuscript; Di Tommaso L reviewed the anatomo-pathological data; Roncalli M and Torzilli G reviewed and approved the manuscript.
Correspondence to: Matteo Donadon, MD, Liver Surgery Unit, Department of General Surgery, University of Milan, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Milan, Italy. matteo.donadon@humanitas.it
Telephone: +39-2-82244502 Fax: +39-2-82244590
Received: April 19, 2013
Revised: May 19, 2013
Accepted: June 1, 2013
Published online: June 27, 2013
Processing time: 68 Days and 17.4 Hours
Revised: May 19, 2013
Accepted: June 1, 2013
Published online: June 27, 2013
Processing time: 68 Days and 17.4 Hours
Core Tip
Core tip: This report describes two interesting cases of patients who developed multiple focal nodular hyperplasias during oxaliplatin-based therapy for colorectal cancer. Such multiple bilateral focal liver lesions were misdiagnosed as colorectal liver metastases, and treated with liver resection. A review of the cases revealed that in both cases the fluorodeoxyglucose-positron emission tomography was negative. A brief review of the literature together with the authors’ comments is included.