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Therapeutic efficacy and multitarget mechanisms of traditional Chinese medicine in hereditary liver diseases: Insights into bioactive components
Meng-Juan Tang, Hong-Yi Wang, Mei-Yin Wu, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, China
Ke-Yi Feng, School of Clinical Medicine, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, China
Zhen-Jie Zhuang, Peng-Hua Li, Xiao-Xiao Mi, Institute of Translational Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China
Jun-Ping Shi, Department of Infectious Diseases and Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China
Co-first authors: Meng-Juan Tang and Ke-Yi Feng.
Co-corresponding authors: Jun-Ping Shi and Xiao-Xiao Mi.
Author contributions: Tang MJ, Feng KY, Mi XX, and Shi JP drafted the original manuscript; Mi XX and Shi JP conceived and designed the study, acquired funding, and critically reviewed and edited the final version as co-corresponding authors; Tang MJ and Feng KY interpreted the data and revised it critically for important intellectual content as co-first authors; Zhuang ZJ, Wang HY, and Wu MY participated in drafting the original manuscript and contributed to manuscript revision; Li PH performed chemical structure analysis. All authors approved the final version to publish.
AI contribution statement: Portions of this manuscript were edited using AI tools solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Supported by Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China, No. LHDMZ24H030001; National Natural Science Foundation of China, No. 82470599; and Hangzhou Municipal Health and Wellness Project, No. 2023WJC149.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Xiao-Xiao Mi, Institute of Translational Medicine, The Affiliated Hospital of Hangzhou Normal University, No. 126 Wenzhoulu, Hangzhou 310015, Zhejiang Province, China. mixiaoxiao1987@163.com
Received: June 2, 2026
Revised: July 2, 2026
Accepted: July 27, 2026
Published online: September 27, 2026
Processing time: 107 Days and 7.8 Hours
Revised: July 2, 2026
Accepted: July 27, 2026
Published online: September 27, 2026
Processing time: 107 Days and 7.8 Hours
Core Tip
Core Tip: This review highlights the therapeutic potential of traditional Chinese medicine in hereditary liver diseases, emphasizing its proposed multitarget mechanisms, regulating ion homeostasis, oxidative stress, cell death, and gut-liver axis. It explores bioactive components (alkaloids and flavonoids) and compound formulas (e.g., Gandouling Decoction) guided by Jun-Chen-Zuo-Shi principles, addressing challenges (bioavailability and quality control) and future directions (multiomics and nanotechnology) to complement western medicine via holistic, mechanism-based therapy.