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Chrono-metabolic regulation of hepatic fibrosis via NR1D1-mediated hepatic stellate cell activation
Hou-Shu Tu, Meng-Lin Chen, Ling He, Department of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China
Jing Hong, Department of Otorhinolaryngology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, Jiangxi Province, China
Ling He, Department of Gastroenterology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, Jiangxi Province, China
Author contributions: Tu HS and Chen ML conceived and drafted the manuscript; Hong J provided critical content review; He L supervised and revised the work. All authors approved the final manuscript.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest related to this work.
Corresponding author: Ling He, PhD, Professor, Department of Gastroenterology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, No. 445 Bayi Avenue, Nanchang 330006, Jiangxi Province, China. heling118@126.com
Received: December 28, 2025
Revised: January 13, 2026
Accepted: January 23, 2026
Published online: August 27, 2026
Processing time: 235 Days and 2.5 Hours
Revised: January 13, 2026
Accepted: January 23, 2026
Published online: August 27, 2026
Processing time: 235 Days and 2.5 Hours
Core Tip
Core Tip: This review summarizes the NR1D1-centered chrono-metabolic regulation of hepatic fibrosis, detailing how circadian rhythms, HIF-1α signaling, and ammonia-mediated hepatic stellate cell activation converge. It emphasizes the therapeutic potential of chrono-informed interventions using pharmacological agents and natural compounds, offering a translational roadmap for more precise and effective antifibrotic strategies.