Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
Time-dependent predictive accuracy of noninvasive liver scores for chronic kidney disease onset in metabolic dysfunction-associated steatotic liver disease
Huttakan Navadurong, Supatsri Sethasine, Division of Gastroenterology and Hepatology, Department of Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand
Padoemwut Teerawongsakul, Division of Cardiology, Department of Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand
Thananda Trakarnvanich, Division of Nephrology, Department of Medicine, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand
Witchakorn Ruamtawee, Clinical Research Center, Research Facilitation Division, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand
Nutachat Treerasoradaj, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand
Author contributions: Navadurong H contributed to conceptualization, investigation, methodology, and writing (original draft preparation, review, and editing); Teerawongsakul P contributed to data collection, data curation, methodology, validation, visualization; Trakarnwanich T contributed to validation and visualization; Ruamtawee W contributed to data curation and formal analyses; Treerasoradaj N contributed to data collection and data curation; Sethasine S contributed to conceptualization, investigation, methodology, and writing (review and editing).
AI contribution statement: The authors used Gemini to improve the English language and readability of the manuscript and Answering-Reviewers. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the final content of the manuscript.
Institutional review board statement: The study protocol was approved by the Vajira Institutional Review Board Institutional Review Board, Faculty of Medicine Vajira Hospital (COA 111/2567).
Informed consent statement: The informed consent was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The data used in the current study are available from the corresponding author upon reasonable request.
Corresponding author: Supatsri Sethasine, MD, Associate Professor, Division of Gastro
Received: May 6, 2026
Revised: June 2, 2026
Accepted: June 29, 2026
Published online: July 27, 2026
Processing time: 84 Days and 1.1 Hours
Revised: June 2, 2026
Accepted: June 29, 2026
Published online: July 27, 2026
Processing time: 84 Days and 1.1 Hours
Core Tip
Core Tip: Nonalcoholic fatty liver disease fibrosis score (NFS) is an independent and reliable predictor of 5-year incident chronic kidney disease in patients with metabolic dysfunction-associated steatotic liver disease. NFS demonstrated superior predictive accuracy compared with liver stiffness measurement and albumin-bilirubin score in this longitudinal study, with performance peaking at 3 years. Baseline NFS assessment should be incorporated into clinical practice to enable early identification of high-risk patients for nephrological intervention and individualized metabolic management.