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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2026; 18(1): 114542
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.114542
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.114542
Enhanced surgical tolerance of schistosomiasis-induced fibrotic liver following treatment with Ziziphus plant extract
Thamer H Alghamdi, Department of Surgery, Al-Baha University, Al Baha 65716, Saudi Arabia
Author contributions: Alghamdi TH contributed to study design, implementation and supervision, and manuscript preparation.
Institutional animal care and use committee statement: The Ethics Committee Board of Faculty of Medicine, Al-Baha University, Kingdom of Saudi Arabia approved the study protocol (Approval No. REC/SUR/BU-FM/2022/59).
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: There is no objection for sharing data.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Thamer H Alghamdi, Associate Professor, Consultant, Department of Surgery, Al-Baha University, Prince Mohammad Bin Saud Road, Al Baha 65716, Saudi Arabia. tthaker@bu.edu.sa
Received: September 23, 2025
Revised: October 9, 2025
Accepted: December 1, 2025
Published online: January 27, 2026
Processing time: 126 Days and 16 Hours
Revised: October 9, 2025
Accepted: December 1, 2025
Published online: January 27, 2026
Processing time: 126 Days and 16 Hours
Core Tip
Core Tip: The present research strongly suggests that Ziziphus spina-christi leaf extract is a powerful agent in protecting the liver from damage induced by Schistosoma mansoni. Furthermore, this study’s data revealed that liver damage is severely influenced by Schistosoma mansoni infection. The Ziziphus spina-christi leaf extract treatment improved biochemical parameters, pro-inflammatory cytokine levels, DNA integrity, and pathological liver outcomes.