Copyright
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2026; 18(1): 113465
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.113465
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.113465
Late hepatotoxicity after treatment for childhood cancer
Jelena Roganovic, Ante Vidovic, Department of Pediatric Oncology and Hematology, Children’s Hospital Zagreb, Zagreb 10000, Zagreb, Grad, Croatia
Ante Vidovic, Department of Pediatrics, University Hospital Center Sestre Milosrdnice, Zagreb 10000, Zagreb, Grad, Croatia
Ana Dordevic, Department of Business Development, Jadran Galenski Laboratorij, Rijeka 51000, Croatia
Author contributions: Vidovic A performed the research and wrote the preliminary draft; Dordevic A contributed to writing and provided technical support for manuscript preparation; Roganovic J provided the input in writing the paper, designed the outline and coordinated the writing of the paper; all the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jelena Roganovic, MD, PhD, Tenured Professor, Department for Pediatric Oncology and Hematology, Children’s Hospital Zagreb, Klaiceva 16, Zagreb 10000, Zagreb, Grad, Croatia. jelena.roganovic02@gmail.com
Received: August 26, 2025
Revised: September 21, 2025
Accepted: November 24, 2025
Published online: January 27, 2026
Processing time: 154 Days and 15.8 Hours
Revised: September 21, 2025
Accepted: November 24, 2025
Published online: January 27, 2026
Processing time: 154 Days and 15.8 Hours
Core Tip
Core Tip: Modern treatment regimens have markedly improved survival rates in children with cancer. However, these advances are accompanied by the risk of long-term health complications, collectively termed late effects. Among these, late hepatic toxicity remains under-investigated despite its potential to cause subtle, progressive, and even life-threatening liver damage. Given the silent nature of liver involvement, ongoing multidisciplinary follow-up of childhood cancer survivors is crucial for early detection, prevention, and timely intervention.