Analysis of gastric electrical rhythm in patients with metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus

doi:10.4254/wjh.v17.i7.109067

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Jul 27, 2025 (publication date) through Jul 25, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Hepatol. Jul 27, 2025; 17(7): 109067
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.109067

Analysis of gastric electrical rhythm in patients with metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus

Xi-Xi Wang, Chun Yan, Su-Juan Wang, Hong Zhu, Chang-Chun Cao, Li Wu, Shuang Wang, Ji Hu, Hong-Hong Zhang

Xi-Xi Wang, Hong Zhu, Chang-Chun Cao, Li Wu, Shuang Wang, Department of Endocrinology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian 223800, Jiangsu Province, China

Chun Yan, Ji Hu, Department of Endocrinology, The Second Afﬁliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China

Su-Juan Wang, Department of Gastroenterology, Sihong Hospital, Suqian 223800, Jiangsu Province, China

Hong-Hong Zhang, Clinical Research Center of Neurological Disease, Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China

Co-first authors: Xi-Xi Wang and Chun Yan.

Co-corresponding authors: Ji Hu and Hong-Hong Zhang.

Author contributions: Wang XX, Wang SJ, and Yan C collected and analyzed the data and wrote the article; Zhu H, Cao CC, Wu L and Wang S collected and analyzed the data; Hu J reviewed and edited the article; Zhang HH designed and supervised the study and edited the article, Zhang HH is the guarantor of this study and, as such, had full access to all the data in the study and takes responsibility for the authenticity of the data and the accuracy of the data analysis; Hu J and Zhang HH have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors.

Supported by Noncommunicable Chronic Diseases-National Science and Technology Major Project, No. 2023ZD0507200; The Suqian Sci Tech Program, No. Z2023106; National Natural Science Foundation of China, No. 82071234, No. 31400947 and No. 82170836; Gusu Talent Program, No. GSWS2022030; and The Clinical Research Center of Neurological Disease of The Second Affiliated Hospital of Soochow University, No. ND2024A02.

Institutional review board statement: The protocol of the present study was approved by the Institutional Review Board of the Second Affiliated Hospital of Soochow University and the Affiliated Suqian Hospital of Xuzhou Medical University, and the approving registration number is JD-HG-2022-07 and 2024036.

Informed consent statement: Informed Consent was not required for this retrospective study.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Hong-Hong Zhang, Professor, Clinical Research Center of Neurological Disease, Department of Endocrinology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou 215000, Jiangsu Province, China. zhanghonghong@suda.edu.cn

Received: May 19, 2025
Revised: June 4, 2025
Accepted: July 8, 2025
Published online: July 27, 2025
Processing time: 68 Days and 19.6 Hours

Core Tip

Core Tip: This study identifies metabolic dysfunction-associated steatotic liver disease (MASLD) as an independent risk factor for diabetic gastric motility disorders (DGMD) in type 2 diabetes patients, confirmed by electrogastrogram. Longer diabetes duration, elevated fasting blood glucose, and lower 25-hydroxyvitamin D levels synergistically increase DGMD risk. Early intervention for MASLD may prevent diabetic gastroparesis.