Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jul 27, 2025; 17(7): 107620
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.107620
Advancing therapeutic vaccines for chronic hepatitis B: Integrating reverse vaccinology and immunoinformatics
Patricia Gita Naully, Marselina Irasonia Tan, Korri Elvanita El Khobar, Caecilia H C Sukowati, Ernawati Arifin Giri-Rachman
Patricia Gita Naully, Marselina Irasonia Tan, Ernawati Arifin Giri-Rachman, School of Life Science and Technology, Institut Teknologi Bandung, Bandung 10432, Jawa Barat, Indonesia
Patricia Gita Naully, Faculty of Health Sciences and Technology, Jenderal Achmad Yani University, Cimahi 40525, Jawa Barat, Indonesia
Korri Elvanita El Khobar, Caecilia H C Sukowati, Eijkman Research Center for Molecular Biology, Research Organization for Health, National Research and Innovation Agency of Indonesia, Jakarta 10430, Indonesia
Caecilia H C Sukowati, Liver Cancer Unit, Fondazione Italiana Fegato ONLUS, Trieste 34149, Friuli Venezia Giulia, Italy
Co-corresponding authors: Caecilia H C Sukowati and Ernawati Arifin Giri-Rachman.
Author contributions: Sukowati CHC and Giri-Rachman EA contribute equally to this study as co-corresponding authors; Naully PG drafted the original manuscript and designed the figures; El Khobar KE and Sukowati CHC wrote part of the manuscript; Tan MI and Giri-Rachman EA proposed and concepted the manuscript topic; Tan MI, Sukowati CHC, and Giri-Rachman EA gave critical suggestions to the final draft; all authors have agreed with the final revisions of the manuscript.
Supported by Riset Unggulan of Institut Teknologi Bandung, No. 125/IT1.B07.1/SPP-DRI/III/2025.
Conflict-of-interest statement: The authors have no conflict of interests to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ernawati Arifin Giri-Rachman, Associate Professor, Senior Scientist, School of Life Science and Technology, Institut Teknologi Bandung, Jl. Ganesa 10, Bandung 10432, Jawa Barat, Indonesia. erna_girirachman@itb.ac.id
Received: March 27, 2025
Revised: April 28, 2025
Accepted: June 13, 2025
Published online: July 27, 2025
Processing time: 120 Days and 23.2 Hours
Core Tip

Core Tip: Chronic hepatitis B (CHB) remains a significant public health concern worldwide where effective alternative therapies are still urgently needed. This review aims to explore the potential role of reverse vaccinology combined with immunoinformatics in advancing therapeutic vaccine design for CHB.