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World J Hepatol. Jul 27, 2025; 17(7): 107520
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.107520
Systemic treatment of liver cancer: Current status and future perspectives
Chun-Bo Li, Yu-Ting Ning, Nai-Ying Shen, Ben Wang, Han Xiao, Gang Luo
Chun-Bo Li, Nai-Ying Shen, Ben Wang, Department of General Surgery, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang 712000, Shaanxi Province, China
Yu-Ting Ning, Department of General Surgery, Xi'an Medical College, Xi'an 710000, Shaanxi Province, China
Han Xiao, Gang Luo, Department of Hepato-Biliary-Pancreatic Surgery, The First Hospital of Jiujiang City, Jiujiang 332000, Jiangxi Province, China
Han Xiao, Gang Luo, Jiujiang City Key Laboratory of Cell Therapy, The First Hospital of Jiujiang City, Jiujiang 332000, Jiangxi Province, China
Co-first authors: Chun-Bo Li and Yu-Ting Ning.
Co-corresponding authors: Han Xiao and Gang Luo.
Author contributions: Xiao H and Luo G contributed to the idea development and manuscript drafting; Li CB, Ning YT, and Shen NY conducted literature collection and manuscript drafting; Wang B contributed to the drafting and polishing of the manuscript.
Supported by the Science and Technology Project of China-Shaanxi Nuclear Industry Group, No. 61230303; the Shaanxi Nuclear Industry 215 Hospital Scientific Research Project, No. 215KYJJ-202214; and the Science and Technology Plan Project of Jiangxi Provincial Health Commission; No. 202510800.
Conflict-of-interest statement: There is no conflict of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gang Luo, Department of General surgery, Jiujiang First People’s Hospital, No. 77 Balihu East Road, Balihu New District, Jiujiang 332000, Jiangxi Province, China. luogangxueshu@163.com
Received: March 26, 2025
Revised: April 26, 2025
Accepted: June 9, 2025
Published online: July 27, 2025
Processing time: 121 Days and 14.3 Hours
Core Tip

Core Tip: Primary liver cancer is a malignant tumor with the fifth highest incidence in the world, and hepatocellular carcinoma is the most common form of primary liver cancer. Due to the insidious disease onset and rapid progression, most liver cancer patients are diagnosed in the intermediate or advanced stages, and surgery is no longer a viable option. This article summarizes the current challenges faced by the systemic treatment of liver cancer and introduces the prospect of future treatment trends.