Liver stiffness measurements in patients with metabolic dysfunction-associated steatotic liver disease: Updates on the method effectiveness and perspectives

doi:10.4254/wjh.v17.i7.106675

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Jul 27, 2025 (publication date) through Jul 28, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 27, 2025; 17(7): 106675
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.106675

Liver stiffness measurements in patients with metabolic dysfunction-associated steatotic liver disease: Updates on the method effectiveness and perspectives

Olga Sukocheva, Tsai-Wing Ow, Damian Harding, Marc Le Mire, Edmund Tse

Olga Sukocheva, Tsai-Wing Ow, Damian Harding, Marc Le Mire, Edmund Tse, Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide 5000, South Australia, Australia

Damian Harding, Edmund Tse, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5000, South Australia, Australia

Author contributions: Sukocheva O and Tse E designed this review and wrote the first draft; Harding D, Ow TW, and Le Mire M edited manuscript, contributed valuable insights, and extended discussion and conclusion sections; Tse E supervised the project; All authors have read and approved the final version of this manuscript.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Olga Sukocheva, Senior Scientist, Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Central Adelaide Local Health Network, Port Road, Adelaide 5000, South Australia, Australia. olga.sukocheva@sa.gov.au

Received: March 4, 2025
Revised: May 1, 2025
Accepted: June 25, 2025
Published online: July 27, 2025
Processing time: 143 Days and 13.5 Hours

Core Tip

Core Tip: Clinical diagnostics of metabolic dysfunction-associated steatotic liver disease (MASLD) relies on non-invasive diagnostic tools, such as transient elastography (TE)/FibroScan^®. TE measures liver stiffness, an important clinical marker of liver fibrosis and cirrhosis. However, TE measurements have limited accuracy in obese patients. This study reviews the limitations of TE-based diagnostics and discusses the combined scoring algorithm. Data review indicates that in patients with MASLD reliable diagnostic accuracy can be achieved by combining FibroScan^® measurements with various blood test-based scores, including agile and fibrosis score indicators.