Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. May 27, 2025; 17(5): 106124
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.106124
Microbial characteristics of gut microbiome dysbiosis in patients with chronic liver disease
Chi Ma, Juan Yang, Xin-Nian Fu, Jiang-Yan Luo, Pei Liu, Xue-Li Zeng, Xin-Yi Li, Shun-Ling Zhang, Sheng Zheng
Chi Ma, Xin-Nian Fu, Jiang-Yan Luo, Pei Liu, Xue-Li Zeng, Xin-Yi Li, Shun-Ling Zhang, Department of Gastroenterology, The Second Affiliated Hospital of Dali University, Kunming 650011, Yunnan Province, China
Juan Yang, Sheng Zheng, Department of Gastroenterology, The Third People’s Hospital of Yunnan Province, Kunming 650011, Yunnan Province, China
Author contributions: Ma C contributed software, resources, data organization, writing of the original manuscript, and project management to the manuscript; Yang J contributed methodology to the manuscript; Fu XN, Luo JY, and Liu P contributed validation to the manuscript; Yang J and Zheng S performed conceptualization and funding acquisition; Yang J, Fu XN, Luo JY, Liu P, Zeng XL, Li XY, Zhang SL, and Zheng S wrote the manuscript; Zeng XL conducted the formal analysis, review and editing; Li XY and Zhang SL conducted the investigation; Zheng S conducted the visualization, supervision; and all authors have read and agreed to the published version of the manuscript.
Supported by the Yunnan Provincial High-Level Science and Technology Talent and Innovation Team Selection Special - Young Academic and Technical Leader Backup Talent Project, No. 202405AC350067; and the Yunnan Provincial Department of Education Scientific Research Fund Project, No. 2024Y919 and No. 2024Y920.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Third People’s Hospital of Yunnan Province, approval No. 2023KY050.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data generated or analyzed during this study are included in its Supplementary material.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sheng Zheng, Associate Professor, Department of Gastroenterology, The Third People’s Hospital of Yunnan Province, No. 292 Beijing Road, Guandu District, Kunming 650011, Yunnan Province, China. zheng_sheng523@163.com
Received: February 17, 2025
Revised: March 28, 2025
Accepted: April 24, 2025
Published online: May 27, 2025
Processing time: 99 Days and 20.3 Hours
Core Tip

Core Tip: The study emphasized the microbial characteristics of gut microbiome dysbiosis at different stages of chronic liver disease (CLD). In this study, 16SrDNA sequencing was used to detect the gut microbiome characteristics in the CLD population. The reduced abundance of short-chain fatty acid-producing bacteria in the intestine, alongside the increased abundance of gram-negative bacteria such as Escherichia_Shigella and Parabacteroides, may promote the progression of CLD by compromising the integrity of the intestinal mucosal barrier. The results of this study may provide new insights for developing novel diagnostic and therapeutic strategies for CLD.