Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 27, 2025; 17(4): 99899
Published online Apr 27, 2025. doi: 10.4254/wjh.v17.i4.99899
Cholestasis in hepatitis E virus infection
Tatsuo Kanda, Reina Sasaki-Tanaka, Takeshi Yokoo, Kazunao Hayashi, Hiroteru Kamimura, Atsunori Tsuchiya, Shuji Terai
Tatsuo Kanda, Division of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma 949-7302, Niigata, Japan
Reina Sasaki-Tanaka, Takeshi Yokoo, Kazunao Hayashi, Hiroteru Kamimura, Atsunori Tsuchiya, Shuji Terai, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8520, Japan
Author contributions: Kanda T and Sasaki-Tanaka R designed the overall concept and outline of the manuscript and wrote the paper; Kanda T, Sasaki-Tanaka R, Yokoo T, Hayashi K, Kamimura H, Tsuchiya A, and Terai S contributed critical revision of the manuscript for important intellectual content; all authors have read and approved the final manuscript.
Supported by the Japan Agency for Medical Research and Development (AMED), No. JP24fk0210132 (Kanda T, Sasaki-Tanaka R and Terai S); and the JSPS KAKENHI, No. JP23K15055 (Sasaki-Tanaka R).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tatsuo Kanda, MD, PhD, Professor, Division of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, 4132 Urasa, Minamiuonuma 949-7302, Niigata, Japan. kandatatsuo@gmail.com
Received: August 2, 2024
Revised: September 21, 2024
Accepted: October 9, 2024
Published online: April 27, 2025
Processing time: 265 Days and 23.2 Hours
Core Tip

Core Tip: Hepatitis E virus (HEV) infection triggers severe jaundice and prolonged cholestasis in patients with genetic variants in adenosine triphosphatase phospholipid transporting 8B1 (ATP8B1), adenosine triphosphate-binding cassette (ABC) protein B4, ABCB11, Myosin VB and/or farnesoid X receptor (FXR/NR1H4). Genomic mutations associated with hepatocanalicular transporter proteins occasionally cause cholestasis. HEV infection may trigger severe jaundice and prolonged cholestasis in patients with these genomic mutations.