Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 27, 2025; 17(4): 105583
Published online Apr 27, 2025. doi: 10.4254/wjh.v17.i4.105583
Deadly intersection: Schistosomiasis, hepatopulmonary syndrome, and cirrhosis
David Jerez Diaz, Patrick Twohig
David Jerez Diaz, Internal Medicine, Florida State University, Sarasota Memorial Hospital, Sarasota, FL 34239, United States
Patrick Twohig, Department of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY 14682, United States
Author contributions: Jerez DJ and Twohig P contributed to this paper; Twohig P designed the overall concept and outline of the manuscript; Jerez D contributed to the discussion and design of the manuscript; Jerez D and Twohig P both contributed to the writing, editing of the manuscript, and review of the literature.
Conflict-of-interest statement: David Jerez and Patrick Twohig have nothing to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Patrick Twohig, MD, Assistant Professor, Department of Gastroenterology and Hepatology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14682, United States. patrick_twohig@urmc.rochester.edu
Received: January 30, 2025
Revised: March 3, 2025
Accepted: March 12, 2025
Published online: April 27, 2025
Processing time: 87 Days and 5.5 Hours
Core Tip

Core Tip: Schistosomiasis, hepatopulmonary syndrome, and cirrhosis represents a perfect storm of pathophysiological complexity which can significantly worsen survival in those infected and with liver disease. Diagnostic and therapeutic challenges abound in disproportionately affected resource-limited settings where advanced imaging, pulmonary function testing, and liver transplantation may be scarce or unavailable.