Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 27, 2025; 17(4): 104890
Published online Apr 27, 2025. doi: 10.4254/wjh.v17.i4.104890
Incidence and efficacy of strategies for preventing hepatic encephalopathy following transjugular intrahepatic portosystemic shunt: A meta-analysis
Xiao-Tong Xu, Min-Jie Jiang, Yun-Lai Fu, Fang Xie, Jian-Jun Li, Qing-Hua Meng
Xiao-Tong Xu, Jian-Jun Li, Qing-Hua Meng, Hepatic Disease and Oncology Minimally Invasive Interventional Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Xiao-Tong Xu, Yun-Lai Fu, Fang Xie, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Min-Jie Jiang, Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Co-corresponding authors: Jian-Jun Li and Qing-Hua Meng.
Author contributions: Li JJ and Meng QH contribute equally to this study as co-corresponding authors; Xu XT, Jiang MJ, and Fu YL contributed to the literature database retrieval, data collection, and data extraction; Xu XT, Xie F, Li JJ, and Meng QH conceptualized the topic; Li JJ, Xie F, and Meng QH reviewed the article; Li JJ and Meng QH participated and provided valuable feedback, ensuring the quality of the article and contributing as co-corresponding authors; all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All authors disclosed no relevant relationships.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qing-Hua Meng, Hepatic Disease and Oncology Minimally Invasive Interventional Center, Beijing Youan Hospital, Capital Medical University, No. 8 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China. meng_qh0805@ccmu.edu.cn
Received: January 5, 2025
Revised: February 27, 2025
Accepted: April 7, 2025
Published online: April 27, 2025
Processing time: 109 Days and 21.6 Hours
Core Tip

Core Tip: Hepatic encephalopathy (HE) is a common complication after transjugular intrahepatic portosystemic shunt (TIPS) that affects the quality of life of patients and their families. However, controversy exists regarding about whether TIPS patients need medication to prevent and reduce HE occurrence after surgery. We found through a meta-analysis that the HE incidence after TIPS surgery is relatively high and that drug prevention can significantly reduce HE occurrence. Moreover, current prevention strategies are summarized to provide guidance for future clinical research.