©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2025; 17(2): 98503
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.98503
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.98503
Gilbert’s syndrome: The good, the bad and the ugly
Arjuna Priyadarsin De Silva, Nilushi Nuwanshika, Madunil Anuk Niriella, Hithanadura Janaka de Silva, Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka
Co-corresponding authors: Arjuna Priyadarsin De Silva and Nilushi Nuwanshika.
Author contributions: De Silva AP and Nuwanshika N wrote the original draft, they contributed equally as co-corresponding authors; Niriella MA and de Silva HJ investigated and reviewed the manuscript; and all authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Arjuna Priyadarsin De Silva, MD, Department of Medicine, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama 11010, Sri Lanka.
Received: June 27, 2024
Revised: November 14, 2024
Accepted: December 20, 2024
Published online: February 27, 2025
Processing time: 237 Days and 20 Hours
Revised: November 14, 2024
Accepted: December 20, 2024
Published online: February 27, 2025
Processing time: 237 Days and 20 Hours
Core Tip
Core Tip: Gilbert’s syndrome is a benign hereditary disorder characterized by mild hyperbilirubinemia. This comprehensive review delves into the genetic and environmental determinants of Gilbert’s syndrome, elucidating its possible protective role against cardiovascular diseases, metabolic disorders, and certain malignancies, attributed to the antioxidant properties of bilirubin. Additionally, it addresses potential complications during pregnancy and the neonatal period, alongside a possible association with severe schizophrenia. Emphasis is placed on the importance of early diagnosis and patient education to mitigate unnecessary medical interventions and optimize clinical outcomes.