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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 27, 2025; 17(10): 112104
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.112104
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.112104
Predicting steroid response in acute alcohol-associated hepatitis: Beyond biomarkers of alcohol consumption
Jin-Wei Zhang, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Author contributions: Zhang JW designed the overall concept and outline of the manuscript, contributed to the discussion and design of the manuscript, the writing and editing of the manuscript, illustrations, and review of the literature, read and approved the final version of the manuscript to be published.
Supported by National Natural Science Foundation of China, No. 82170406 and No. 81970238.
Conflict-of-interest statement: The author has no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Wei Zhang, PhD, Professor, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, No. 345 Lingling Road, Shanghai 200032, China. jinweizhang@sioc.ac.cn
Received: July 17, 2025
Revised: August 30, 2025
Accepted: September 17, 2025
Published online: October 27, 2025
Processing time: 101 Days and 23.5 Hours
Revised: August 30, 2025
Accepted: September 17, 2025
Published online: October 27, 2025
Processing time: 101 Days and 23.5 Hours
Core Tip
Core Tip: This manuscript offers a thorough analysis of Sabatose et al's study exploring predictors of steroid response in acute alcohol-associated hepatitis (AAH). The study examines the role of alcohol consumption biomarkers (such as phosphatidylethanol) and clinical factors, revealing that age, pre-steroid albumin, and bilirubin levels-rather than alcohol-related markers-are key predictors of non-response. The identification of poorer outcomes in non-responders, coupled with insights into limitations and future research directions, provides valuable guidance for clinical decision-making and the development of improved strategies for AAH management.