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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 27, 2025; 17(10): 110833
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.110833
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.110833
Helicobacter pylori infection as a risk factor in the development of metabolic dysfunction-associated steatotic liver disease
Olga V Smirnova, Aleksander A Sinyakov, Edward V Kasparov, Laboratory of Clinical Path
Author contributions: Smirnova OV wrote the original draft; Sinyakov AA contributed to conceptualization, writing, reviewing and editing; Smirnova OV, Sinyakov AA, and Kasparov EV participated in manuscript drafting. All the authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Olga V Smirnova, Professor, Laboratory of Clinical Pathophysiology, Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”, Separate Subdivision Research Institute for Medical Problems of the North, Partizana Zheleznyaka Street 3G, Krasnoyarsk 660022, Russia. ovsmirnova71@mail.ru
Received: June 17, 2025
Revised: July 4, 2025
Accepted: August 28, 2025
Published online: October 27, 2025
Processing time: 133 Days and 5 Hours
Revised: July 4, 2025
Accepted: August 28, 2025
Published online: October 27, 2025
Processing time: 133 Days and 5 Hours
Core Tip
Core Tip: The editorial discusses risk factors (Helicobacter pylori infection, proinflammatory cytokines, adipokines, mitochondrial dysfunction, oxidative stress, insulin resistance, gut microbiota, and other indicators) in the development of metabolic dysfunction-associated steatotic liver disease. This issue is covered in an article by Ye et al, they show that in a large cross-sectional study involving 28624 adults, it was revealed that Helicobacter pylori infection is correlated with metabolic disturbances, particularly in obese and older individuals. This study is distinguished by its extremely promising and strategically new objective and a very impressive methodological level of research.