Observational Study
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World J Hepatol. Jan 27, 2025; 17(1): 101212
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.101212
Comparison of different severity scores in correlating hemoglobin levels with the severity of hepatic decompensation: An observational study
Himayat Ullah, Sarwat Huma, Ghulam Yasin, Muhammad Ashraf, Nafisa Tahir, Qazi Tahir Uddin, Hossam Shabana, Mostafa A R Hussein, Abdulrahman Shalaby, Mohammad Mossaad Alsayyad, Ashraf Said, Ali Farahat, Hani Ismail Hamed, Hazem Sayed Ahmed Ayoub, Mohammed S Imam, Essam Elmahdi
Himayat Ullah, Muhammad Ashraf, Hossam Shabana, Department of Medicine, College of Medicine at Shaqra, Shaqra University, Shaqra 15526, Saudi Arabia
Sarwat Huma, Health Professions Education, Health Services Academy, Islamabad 44000, Pakistan
Ghulam Yasin, Department of Orthopedics, College of Medicine at Shaqra, Shaqra University, Shaqra 15526, Saudi Arabia
Nafisa Tahir, Department of Medicine, NUST School of Health Sciences, Islamabad 44000, Pakistan
Qazi Tahir Uddin, Department of Surgery, College of Medicine at Shaqra, Shaqra University, Shaqra 15526, Saudi Arabia
Hossam Shabana, Mostafa A R Hussein, Abdulrahman Shalaby, Ashraf Said, Ali Farahat, Hani Ismail Hamed, Hazem Sayed Ahmed Ayoub, Mohammed S Imam, Faculty of Medicine, Al-Azhar University, Cairo 11865, Egypt
Mohammad Mossaad Alsayyad, Faculty of Medicine for Boys, Al-Azhar University, New Damietta 34517, Egypt
Essam Elmahdi, Faculty of Medicine, Mansoura University, Mansoura 35511, Egypt
Author contributions: Ullah H, Huma S, and Tahir N were responsible for conceptualization, and data collection; Ullah H, Huma S, Yasin G, and Ashraf M were responsible for writing of the initial draft; Ullah H, Tahir Uddin Q, Shabana H, Hussein MAR, Shalaby A, Mossaad Alsayyad M, Said A, Farahat A, Hamed HI, Ayoub HSA, Imam MS, and Elmahdi E were responsible for writing, editing, and revision of drafts; all of the authors read and approved the final version of the manuscript to be published.
Institutional review board statement: Approved by the Institutional Review Board of Hayatabad Medical Complex, Peshawar, No. 597/HEC/BPSC/2021, dated February 2, 2022.
Informed consent statement: Written Informed consent was taken from all the participants.
Conflict-of-interest statement: The authors have no conflict of interest to disclose.
Data sharing statement: This will be provided on the authorized request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sarwat Huma, Doctor, MBBS, Academic Fellow, Research Fellow, Health Professions Education, Health Services Academy, Health Services Academy Park Road, Chak Shahzad, Islamabad 44000, Pakistan. sarwathuma007@gmail.com
Received: September 9, 2024
Revised: October 27, 2024
Accepted: November 20, 2024
Published online: January 27, 2025
Processing time: 120 Days and 14.9 Hours
Core Tip

Core Tip: This study investigates the correlation between hemoglobin levels and disease severity in patients with decompensated liver disease. A cohort of 652 patients was assessed using Child-Pugh, model of end-stage liver disease (MELD), and MELD-Na scores to measure disease severity and its association with hemoglobin levels. The analysis revealed a strong inverse correlation, with lower hemoglobin levels associated with higher disease severity. Among the scoring systems, MELD and MELD-Na showed the most significant associations. These findings suggest that hemoglobin levels could serve as a valuable marker in assessing disease progression, potentially improving clinical management for patients with decompensated liver disease.