Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2024; 16(8): 1167-1176
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1167
Gadoxetic acid-enhanced magnetic resonance imaging in the assessment of hepatic sinusoidal obstruction syndrome in a mouse model
Yuan-Yuan Chen, Li Yang, Jun Li, Sheng-Xiang Rao, Ying Ding, Meng-Su Zeng
Yuan-Yuan Chen, Li Yang, Jun Li, Sheng-Xiang Rao, Ying Ding, Meng-Su Zeng, Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Author contributions: Chen YY contributed to the conception, design, acquisition, analysis, interpretation of data, wrote the manuscript; Yang L and Li J collected and preprocessed the data; Rao SX provided supervision and methodology; Ding Y revised the manuscript and gave the final approval of the version to be published; Zeng MS was responsible for conceptualization and supervision.
Supported by the National Science Foundation for Young Scientists of China, No. 81701682.
Institutional animal care and use committee statement: Animal experimental procedures were reviewed and approved by Zhongshan Hospital Institutional Ethics and Animal Care on February 4, 2017.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request at ding.ying@zs-hospital.sh.cn.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Ding, MD, Associate Chief Physician, Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai 200032, China. ding.ying@zs-hospital.sh.cn
Received: May 15, 2024
Revised: July 13, 2024
Accepted: August 2, 2024
Published online: August 27, 2024
Processing time: 97 Days and 23.7 Hours
Core Tip

Core Tip: Neoadjuvant chemotherapy could cause hepatic sinusoidal obstruction syndrome (SOS) in colorectal liver metastases patients and increases postoperative morbidity and mortality. We used a mouse model of monocrotaline-induced hepatic SOS. We confirmed the relationship between magnetic resonance imaging (MRI) parameters T1 relaxation time 20 minutes after enhancement, a reduction in T1 relaxation time and first enhancement slope percentage of the liver parenchyma and hepatic SOS, suggesting a potential method for the assessment of hepatic SOS. Our results also demonstrated that MRI parameters were correlated with organic anion transporter polypeptide 1 levels.