Cheng JY, Shan GY, Wan H, Liu YY, Zhang YX, Shi WN, Li HJ. Hepatitis B virus-induced cirrhosis: Mechanisms, global variations, and treatment advances. World J Hepatol 2024; 16(12): 1515-1523 [PMID: 39744198 DOI: 10.4254/wjh.v16.i12.1515]
Corresponding Author of This Article
Hai-Jun Li, MD, PhD, Associate Professor, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130061, Jilin Province, China. hjli2012@jlu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
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Cheng JY, Shan GY, Wan H, Liu YY, Zhang YX, Shi WN, Li HJ. Hepatitis B virus-induced cirrhosis: Mechanisms, global variations, and treatment advances. World J Hepatol 2024; 16(12): 1515-1523 [PMID: 39744198 DOI: 10.4254/wjh.v16.i12.1515]
Jun-Ya Cheng, Department of Bioengineering, Pharmacy School of Jilin University, Changchun 130061, Jilin Province, China
Guan-Yue Shan, Hui Wan, Yi-Ying Liu, Yu-Xin Zhang, Wen-Na Shi, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
Hai-Jun Li, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
Author contributions: Cheng JY, Wan H, Shan GY and Shi WN collected the information; Zhang YX and Liu YY drew and modified the illustrations; Cheng JY wrote the paper; Li HJ revised the paper.
Supported by National Natural Science Foundation of China, No. 81970529; and the Natural Science Foundation of Jilin Province, No. 20230508074RC and No. YDZJ202401218ZYTS.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Corresponding author: Hai-Jun Li, MD, PhD, Associate Professor, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130061, Jilin Province, China. hjli2012@jlu.edu.cn
Received: July 28, 2024 Revised: October 3, 2024 Accepted: October 24, 2024 Published online: December 27, 2024 Processing time: 124 Days and 1.4 Hours
Core Tip
Core Tip: Understanding the global variation in hepatitis B virus-induced cirrhosis highlights the complex interplay between viral factors, host genetics, and environmental influences. Cirrhosis due to chronic hepatitis B virus (CHB) infection results from a cascade of fibrosis processes driven by persistent viral replication and immune-mediated hepatocyte injury. Over time, evolving antiviral treatment strategies have transformed from interferon-based therapies to nucleos(t)ide analogs, such as tenofovir, which effectively inhibit viral replication and attenuate liver injury. Future research should focus on elucidating new therapeutic targets to improve treatment efficacy and reduce the global burden of cirrhosis associated with CHB infection.
